Extracellular Vesicles in Hematological Disorders

Extracellular vesicles (EVs), comprised of exosomes, microparticles, apoptotic bodies, and other microvesicles, are shed from a variety of cells upon cell activation or apoptosis. EVs promote clot formation, mediate pro-inflammatory processes, transfer proteins and miRNA to cells, and induce cell si...

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Main Authors:	Anat Aharon, Annie Rebibo-Sabbah, Inna Tzoran, Carina Levin
Format:	Article
Language:	English
Published:	Rambam Health Care Campus 2014-10-01
Series:	Rambam Maimonides Medical Journal
Subjects:	Extracellular vesicles exosomes microRNA thrombogenicity hemoglobinopathies leukemia myeloma lymphomas
Online Access:	http://rmmj.org.il/Pages/ArticleHTM.aspx?manuId=440

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spelling	doaj-83402a8e5de643a19c1e07b71195e4442020-11-24T22:59:02ZengRambam Health Care CampusRambam Maimonides Medical Journal2076-91722014-10-0154e003210.5041/RMMJ.10166Extracellular Vesicles in Hematological DisordersAnat Aharon0Annie Rebibo-Sabbah1Inna Tzoran2Carina Levin3Microvesicles Research Laboratory, Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, IsraelMicrovesicles Research Laboratory, Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, IsraelMicrovesicles Research Laboratory, Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Health Care Campus; Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel; and Department of Internal Medicine C, Rambam Health Care Campus, Haifa, IsraelMicrovesicles Research Laboratory, Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Health Care Campus; Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel; and Pediatric Hematology Unit and Pediatric Department B, Emek Medical Center, Afula, IsraeExtracellular vesicles (EVs), comprised of exosomes, microparticles, apoptotic bodies, and other microvesicles, are shed from a variety of cells upon cell activation or apoptosis. EVs promote clot formation, mediate pro-inflammatory processes, transfer proteins and miRNA to cells, and induce cell signaling that regulates cell differentiation, proliferation, migration, invasion, and apoptosis. This paper will review the contribution of EVs in hematological disorders, including hemoglobinopathies (sickle cell disease, thalassemia), paroxysmal nocturnal hemoglobinuria, and hematological malignancies (lymphomas, myelomas, and acute and chronic leukemias).http://rmmj.org.il/Pages/ArticleHTM.aspx?manuId=440Extracellular vesiclesexosomesmicroRNAthrombogenicityhemoglobinopathiesleukemiamyelomalymphomas
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anat Aharon Annie Rebibo-Sabbah Inna Tzoran Carina Levin
spellingShingle	Anat Aharon Annie Rebibo-Sabbah Inna Tzoran Carina Levin Extracellular Vesicles in Hematological Disorders Rambam Maimonides Medical Journal Extracellular vesicles exosomes microRNA thrombogenicity hemoglobinopathies leukemia myeloma lymphomas
author_facet	Anat Aharon Annie Rebibo-Sabbah Inna Tzoran Carina Levin
author_sort	Anat Aharon
title	Extracellular Vesicles in Hematological Disorders
title_short	Extracellular Vesicles in Hematological Disorders
title_full	Extracellular Vesicles in Hematological Disorders
title_fullStr	Extracellular Vesicles in Hematological Disorders
title_full_unstemmed	Extracellular Vesicles in Hematological Disorders
title_sort	extracellular vesicles in hematological disorders
publisher	Rambam Health Care Campus
series	Rambam Maimonides Medical Journal
issn	2076-9172
publishDate	2014-10-01
description	Extracellular vesicles (EVs), comprised of exosomes, microparticles, apoptotic bodies, and other microvesicles, are shed from a variety of cells upon cell activation or apoptosis. EVs promote clot formation, mediate pro-inflammatory processes, transfer proteins and miRNA to cells, and induce cell signaling that regulates cell differentiation, proliferation, migration, invasion, and apoptosis. This paper will review the contribution of EVs in hematological disorders, including hemoglobinopathies (sickle cell disease, thalassemia), paroxysmal nocturnal hemoglobinuria, and hematological malignancies (lymphomas, myelomas, and acute and chronic leukemias).
topic	Extracellular vesicles exosomes microRNA thrombogenicity hemoglobinopathies leukemia myeloma lymphomas
url	http://rmmj.org.il/Pages/ArticleHTM.aspx?manuId=440
work_keys_str_mv	AT anataharon extracellularvesiclesinhematologicaldisorders AT annierebibosabbah extracellularvesiclesinhematologicaldisorders AT innatzoran extracellularvesiclesinhematologicaldisorders AT carinalevin extracellularvesiclesinhematologicaldisorders
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Extracellular Vesicles in Hematological Disorders

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