Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case
ABSTRACT Spindle cell squamous cell carcinoma of the tongue is a rare variant of squamous cell carcinoma. This paper reports the case of a spindle cell squamous cell carcinoma of the tongue, in a 64-year-old male patient, and presents a review of the etiopathogenesis, clinicopathological and immunoh...
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doaj-8343cf7df37c40dc95b7b9b5aed8c3142020-11-25T00:40:40ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-638517110.31744/einstein_journal/2019rc4610S1679-45082019000100501Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare caseDiego Filipe Bezerra SilvaHellen Bandeira de Pontes SantosJorge Esquiche LeónDaliana Queiroga de Castro GomesPollianna Muniz AlvesCassiano Francisco Weege NonakaABSTRACT Spindle cell squamous cell carcinoma of the tongue is a rare variant of squamous cell carcinoma. This paper reports the case of a spindle cell squamous cell carcinoma of the tongue, in a 64-year-old male patient, and presents a review of the etiopathogenesis, clinicopathological and immunohistochemical features and treatment of the malignancy. The patient presented for evaluation of a painful swelling on his tongue. Extraoral examination revealed palpable submandibular and superior cervical lymph nodes. Based on the presumptive diagnoses of squamous cell carcinoma or malignant salivary gland neoplasm, an incisional biopsy was performed. Histopathological analysis showed a proliferation of atypical spindle cells, exhibiting extensive pleomorphism. Tumor cells were positive for vimentin, P53 and alpha-smooth muscle actin, focally positive for epithelial membrane antigen and P63, and negative for pan-cytokeratin (AE1/AE3), CK7, CD138, CD34, CD56, and S-100. The positivity index for Ki-67 was approximately 40%. The diagnosis of spindle cell squamous cell carcinoma was established and the patient was referred to a head and neck surgery service. In the oral cavity, spindle cell squamous cell carcinoma of the tongue is an aggressive variant of squamous cell carcinoma, which usually presents as an exophytic mass located on the tongue of elderly males. Due to its distinct histopathological characteristics, immunohistochemistry is a valuable and helpful tool to establish the diagnosis of spindle cell squamous cell carcinoma of the tongue.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000100501&lng=en&tlng=enCarcinoma, squamous cellMouth/pathologyTongue neoplasms/diagnosisImmunohistochemistry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diego Filipe Bezerra Silva Hellen Bandeira de Pontes Santos Jorge Esquiche León Daliana Queiroga de Castro Gomes Pollianna Muniz Alves Cassiano Francisco Weege Nonaka |
spellingShingle |
Diego Filipe Bezerra Silva Hellen Bandeira de Pontes Santos Jorge Esquiche León Daliana Queiroga de Castro Gomes Pollianna Muniz Alves Cassiano Francisco Weege Nonaka Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case Einstein (São Paulo) Carcinoma, squamous cell Mouth/pathology Tongue neoplasms/diagnosis Immunohistochemistry |
author_facet |
Diego Filipe Bezerra Silva Hellen Bandeira de Pontes Santos Jorge Esquiche León Daliana Queiroga de Castro Gomes Pollianna Muniz Alves Cassiano Francisco Weege Nonaka |
author_sort |
Diego Filipe Bezerra Silva |
title |
Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case |
title_short |
Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case |
title_full |
Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case |
title_fullStr |
Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case |
title_full_unstemmed |
Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case |
title_sort |
clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case |
publisher |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
series |
Einstein (São Paulo) |
issn |
2317-6385 |
description |
ABSTRACT Spindle cell squamous cell carcinoma of the tongue is a rare variant of squamous cell carcinoma. This paper reports the case of a spindle cell squamous cell carcinoma of the tongue, in a 64-year-old male patient, and presents a review of the etiopathogenesis, clinicopathological and immunohistochemical features and treatment of the malignancy. The patient presented for evaluation of a painful swelling on his tongue. Extraoral examination revealed palpable submandibular and superior cervical lymph nodes. Based on the presumptive diagnoses of squamous cell carcinoma or malignant salivary gland neoplasm, an incisional biopsy was performed. Histopathological analysis showed a proliferation of atypical spindle cells, exhibiting extensive pleomorphism. Tumor cells were positive for vimentin, P53 and alpha-smooth muscle actin, focally positive for epithelial membrane antigen and P63, and negative for pan-cytokeratin (AE1/AE3), CK7, CD138, CD34, CD56, and S-100. The positivity index for Ki-67 was approximately 40%. The diagnosis of spindle cell squamous cell carcinoma was established and the patient was referred to a head and neck surgery service. In the oral cavity, spindle cell squamous cell carcinoma of the tongue is an aggressive variant of squamous cell carcinoma, which usually presents as an exophytic mass located on the tongue of elderly males. Due to its distinct histopathological characteristics, immunohistochemistry is a valuable and helpful tool to establish the diagnosis of spindle cell squamous cell carcinoma of the tongue. |
topic |
Carcinoma, squamous cell Mouth/pathology Tongue neoplasms/diagnosis Immunohistochemistry |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000100501&lng=en&tlng=en |
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