Exploring the effect of network topology, mRNA and protein dynamics on gene regulatory network stability
Maintaining protein expression levels is essential to cellular homeostasis. Here, the authors investigate how transcription factors affect the stability of protein expression in a gene regulatory network, and highlight the importance of network topology.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20472-x |
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doaj-8344d6f0b14f47efb0ad50b8889fd622 |
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Article |
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doaj-8344d6f0b14f47efb0ad50b8889fd6222021-01-10T12:19:30ZengNature Publishing GroupNature Communications2041-17232021-01-0112111010.1038/s41467-020-20472-xExploring the effect of network topology, mRNA and protein dynamics on gene regulatory network stabilityYipei Guo0Ariel Amir1John A. Paulson School of Engineering and Applied Sciences, Harvard UniversityJohn A. Paulson School of Engineering and Applied Sciences, Harvard UniversityMaintaining protein expression levels is essential to cellular homeostasis. Here, the authors investigate how transcription factors affect the stability of protein expression in a gene regulatory network, and highlight the importance of network topology.https://doi.org/10.1038/s41467-020-20472-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yipei Guo Ariel Amir |
| spellingShingle |
Yipei Guo Ariel Amir Exploring the effect of network topology, mRNA and protein dynamics on gene regulatory network stability Nature Communications |
| author_facet |
Yipei Guo Ariel Amir |
| author_sort |
Yipei Guo |
| title |
Exploring the effect of network topology, mRNA and protein dynamics on gene regulatory network stability |
| title_short |
Exploring the effect of network topology, mRNA and protein dynamics on gene regulatory network stability |
| title_full |
Exploring the effect of network topology, mRNA and protein dynamics on gene regulatory network stability |
| title_fullStr |
Exploring the effect of network topology, mRNA and protein dynamics on gene regulatory network stability |
| title_full_unstemmed |
Exploring the effect of network topology, mRNA and protein dynamics on gene regulatory network stability |
| title_sort |
exploring the effect of network topology, mrna and protein dynamics on gene regulatory network stability |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-01-01 |
| description |
Maintaining protein expression levels is essential to cellular homeostasis. Here, the authors investigate how transcription factors affect the stability of protein expression in a gene regulatory network, and highlight the importance of network topology. |
| url |
https://doi.org/10.1038/s41467-020-20472-x |
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AT yipeiguo exploringtheeffectofnetworktopologymrnaandproteindynamicsongeneregulatorynetworkstability AT arielamir exploringtheeffectofnetworktopologymrnaandproteindynamicsongeneregulatorynetworkstability |
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