The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation

The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation

Abstract Background Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification. Methods Three hundred twenty-nine EAC cases were available in Tissue Microarrays (TMA) format. A discov...

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Bibliographic Details
Main Authors: Matthew P. Humphries, Stephanie G. Craig, Rafal Kacprzyk, Natalie C. Fisher, Victoria Bingham, Stephen McQuaid, Graeme I. Murray, Damian McManus, Richard C. Turkington, Jacqueline James, Manuel Salto-Tellez
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Cancer
Subjects:
Esophageal adenocarcinoma
Immune checkpoint
Multiplex IHC
Image analysis
Online Access:http://link.springer.com/article/10.1186/s12885-020-06987-y

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