The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis
Intense muscle contractile activity can result in reactive oxygen species production in humans. Thus, supplementation of antioxidant vitamins has been used to prevent oxidative stress, enhance performance, and improve muscle mass. In this sense, randomized controlled studies on the effect of vitamin...
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doaj-8362f27df6134973a7cfcd908fc276cf2020-11-25T02:56:05ZengHindawi LimitedJournal of Sports Medicine2356-76512314-61762020-01-01202010.1155/2020/35052093505209The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-AnalysisMaurilio T. Dutra0Wagner Rodrigues Martins1Alexandre L. A. Ribeiro2Martim Bottaro3College of Physical Education, University of Brasilia, 70910-900 Brasilia, DF, BrazilSchool of Physical Therapy, University of Brasilia, 72220-275 Brasilia, DF, BrazilCollege of Physical Education, University of Brasilia, 70910-900 Brasilia, DF, BrazilCollege of Physical Education, University of Brasilia, 70910-900 Brasilia, DF, BrazilIntense muscle contractile activity can result in reactive oxygen species production in humans. Thus, supplementation of antioxidant vitamins has been used to prevent oxidative stress, enhance performance, and improve muscle mass. In this sense, randomized controlled studies on the effect of vitamin C and E supplementation combined with strength training (ST) on skeletal muscle mass and strength have been conducted. As these studies have come to ambiguous findings, a better understanding of this topic has yet to emerge. The purpose of the present review is to discuss the current knowledge about the effect of vitamin C and E supplementation on muscle mass and strength gains induced by ST. Search for articles was conducted in the following databases: PubMed/Medline, Web of Science, Scopus, Cochrane Central Register of Controlled Trials, and Google Scholar. This work is in line with the recommendations of the PRISMA statement. Eligible studies were placebo-controlled trials with a minimum of four weeks of ST combined with vitamin C and E supplementation. The quality of each included study was evaluated using the Physiotherapy Evidence Database Scale (PEDro). 134 studies were found to be potentially eligible, but only seven were selected to be included in the qualitative synthesis. A meta-analysis of muscle strength was conducted with 3 studies. Findings from these studies indicate that vitamins C and E has no effect on muscle force production after chronic ST. Most of the evidence suggests that this kind of supplementation does not potentiate muscle growth and could possibly attenuate hypertrophy over time.http://dx.doi.org/10.1155/2020/3505209 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maurilio T. Dutra Wagner Rodrigues Martins Alexandre L. A. Ribeiro Martim Bottaro |
spellingShingle |
Maurilio T. Dutra Wagner Rodrigues Martins Alexandre L. A. Ribeiro Martim Bottaro The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis Journal of Sports Medicine |
author_facet |
Maurilio T. Dutra Wagner Rodrigues Martins Alexandre L. A. Ribeiro Martim Bottaro |
author_sort |
Maurilio T. Dutra |
title |
The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis |
title_short |
The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis |
title_full |
The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis |
title_fullStr |
The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis |
title_sort |
effects of strength training combined with vitamin c and e supplementation on skeletal muscle mass and strength: a systematic review and meta-analysis |
publisher |
Hindawi Limited |
series |
Journal of Sports Medicine |
issn |
2356-7651 2314-6176 |
publishDate |
2020-01-01 |
description |
Intense muscle contractile activity can result in reactive oxygen species production in humans. Thus, supplementation of antioxidant vitamins has been used to prevent oxidative stress, enhance performance, and improve muscle mass. In this sense, randomized controlled studies on the effect of vitamin C and E supplementation combined with strength training (ST) on skeletal muscle mass and strength have been conducted. As these studies have come to ambiguous findings, a better understanding of this topic has yet to emerge. The purpose of the present review is to discuss the current knowledge about the effect of vitamin C and E supplementation on muscle mass and strength gains induced by ST. Search for articles was conducted in the following databases: PubMed/Medline, Web of Science, Scopus, Cochrane Central Register of Controlled Trials, and Google Scholar. This work is in line with the recommendations of the PRISMA statement. Eligible studies were placebo-controlled trials with a minimum of four weeks of ST combined with vitamin C and E supplementation. The quality of each included study was evaluated using the Physiotherapy Evidence Database Scale (PEDro). 134 studies were found to be potentially eligible, but only seven were selected to be included in the qualitative synthesis. A meta-analysis of muscle strength was conducted with 3 studies. Findings from these studies indicate that vitamins C and E has no effect on muscle force production after chronic ST. Most of the evidence suggests that this kind of supplementation does not potentiate muscle growth and could possibly attenuate hypertrophy over time. |
url |
http://dx.doi.org/10.1155/2020/3505209 |
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