Reliability of multiparametric prostatic MRI quantitative data in the evaluation of prostate cancer aggressiveness

• Main Authors: Haisam Atta, Tarek M. Elsaba, Hesham M. Hassan, Moemen M. Hafez, Hassan A. Aboellela, Hisham Imam
• Format: Article
• Language: English
• Published: SpringerOpen 2017-09-01
• Series: The Egyptian Journal of Radiology and Nuclear Medicine
• Online Access: http://www.sciencedirect.com/science/article/pii/S0378603X17300773

Purpose: To compare the quantitative data of multiparametric prostatic MRI with Gleason scores of histopathological analysis. Materials and methods: One hundred twenty-two patients performed Multiparametric MRI of the prostate. Functional MRI quantitative data (including diffusion with mean ADC value and spectroscopic metabolic ratio) where the DWI is employing b 50, 400, 800, 1000 and 2000 sec/mm2 and multivoxel MR spectroscopy compared with of Gleason scores of histopathological results. Malignant cases are classified into three groups according to their Gleason score as group I with Gleason score â¤6, group II Gleason score 7, while Gleason score 8â10 stratified as Group III. Results: The histopathological analysis reveals 78 malignant cases and 44 benign Cases. The significant statistical difference between group I and the other two groups (p < 0.001) regarding the quantitative mean ADC value and metabolic spectroscopic ratio. No significant statistical difference between group II and III with p = 0.2 for mean ADC difference and p = 0.8 for the metabolic spectroscopic ratio with a weak negative correlation between ADCand Gleason score [rs = â0.26] and significant positive correlation (p = 0.02) for MRSI metabolic ratio [rs = 0.2]. Conclusion: The quantitative data of functional imaging of the prostate is reliable in evaluating prostatic cancer aggressiveness and proper construction of therapeutic plan. Keywords: mpMRI prostate cancer aggressiveness