ALLOGENEIC TRANSPLANTATION FOR CHRONIC LYMPHOCYTIC LEUKEMIA
Even if Chronic lymphocytic leukemia (CLL) often has an indolent behavior with good responsiveness to cytoreductive treatment, about 20% of the patients, so called "poor-risk" patients, show an aggressive course and die within a few years despite early intensive therapies. Criteria for poo...
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doaj-836e6abd6cc948808d6bb172406fae512020-11-25T00:19:42ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062010-08-0122e2010026e201002610.4084/mjhid.2010.02667ALLOGENEIC TRANSPLANTATION FOR CHRONIC LYMPHOCYTIC LEUKEMIALuca Laurenti0Michela Tarnani1Patrizia Chiusolo2Federica Sorà3Simona Sica4pol. a gemellipol. a gemellipol. a gemellipol. a gemellipol. a gemelliEven if Chronic lymphocytic leukemia (CLL) often has an indolent behavior with good responsiveness to cytoreductive treatment, about 20% of the patients, so called "poor-risk" patients, show an aggressive course and die within a few years despite early intensive therapies. Criteria for poor-risk disease according to the European Bone Marrow Transplantation (EBMT) CLL Transplant Consensus are: purine analogue refractoriness, early relapse after purine analogue combination therapy, CLL with p53 lesion requiring treatment. Allogeneic transplant has potential curative role in CLL, however burden with very high transplant related mortality (TRM) rates of 38-50%: A major advance in reducing the short-term morbidity and mortality of allogeneic stem cell transplantation (SCT) has been the introduction of non-myeloablative or reduced intensity conditioning (RIC) regimens to allow engraftment of allogeneic stem cells. There is no doubt that the crucial therapeutic principle of allo-SCT in CLL is graft versus leukemia (GVL) activity. The major complications of allogeneic SCT in CLL are: chronic graft-versus-host-disease (GVHD) affecting quality of life, high graft rejection and infection rates rates correlated with preexisting immunosuppression. Disease relapse remains the major cause of failure after RIC allo-HCT in CLL patients. Sensitive minimal residual disease (MRD) quantification has strong prognostic impact after transplant.http://www.mjhid.org/index.php/mjhid/article/view/174Chronic Lymphocytic LeukemiaFludarabineallogeneic transplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luca Laurenti Michela Tarnani Patrizia Chiusolo Federica Sorà Simona Sica |
spellingShingle |
Luca Laurenti Michela Tarnani Patrizia Chiusolo Federica Sorà Simona Sica ALLOGENEIC TRANSPLANTATION FOR CHRONIC LYMPHOCYTIC LEUKEMIA Mediterranean Journal of Hematology and Infectious Diseases Chronic Lymphocytic Leukemia Fludarabine allogeneic transplantation |
author_facet |
Luca Laurenti Michela Tarnani Patrizia Chiusolo Federica Sorà Simona Sica |
author_sort |
Luca Laurenti |
title |
ALLOGENEIC TRANSPLANTATION FOR CHRONIC LYMPHOCYTIC LEUKEMIA |
title_short |
ALLOGENEIC TRANSPLANTATION FOR CHRONIC LYMPHOCYTIC LEUKEMIA |
title_full |
ALLOGENEIC TRANSPLANTATION FOR CHRONIC LYMPHOCYTIC LEUKEMIA |
title_fullStr |
ALLOGENEIC TRANSPLANTATION FOR CHRONIC LYMPHOCYTIC LEUKEMIA |
title_full_unstemmed |
ALLOGENEIC TRANSPLANTATION FOR CHRONIC LYMPHOCYTIC LEUKEMIA |
title_sort |
allogeneic transplantation for chronic lymphocytic leukemia |
publisher |
PAGEPress Publications |
series |
Mediterranean Journal of Hematology and Infectious Diseases |
issn |
2035-3006 |
publishDate |
2010-08-01 |
description |
Even if Chronic lymphocytic leukemia (CLL) often has an indolent behavior with good responsiveness to cytoreductive treatment, about 20% of the patients, so called "poor-risk" patients, show an aggressive course and die within a few years despite early intensive therapies. Criteria for poor-risk disease according to the European Bone Marrow Transplantation (EBMT) CLL Transplant Consensus are: purine analogue refractoriness, early relapse after purine analogue combination therapy, CLL with p53 lesion requiring treatment.
Allogeneic transplant has potential curative role in CLL, however burden with very high transplant related mortality (TRM) rates of 38-50%:
A major advance in reducing the short-term morbidity and mortality of allogeneic stem cell transplantation (SCT) has been the introduction of non-myeloablative or reduced intensity conditioning (RIC) regimens to allow engraftment of allogeneic stem cells. There is no doubt that the crucial therapeutic principle of allo-SCT in CLL is graft versus leukemia (GVL) activity.
The major complications of allogeneic SCT in CLL are: chronic graft-versus-host-disease (GVHD) affecting quality of life, high graft rejection and infection rates rates correlated with preexisting immunosuppression. Disease relapse remains the major cause of failure after RIC allo-HCT in CLL patients.
Sensitive minimal residual disease (MRD) quantification has strong prognostic impact after transplant. |
topic |
Chronic Lymphocytic Leukemia Fludarabine allogeneic transplantation |
url |
http://www.mjhid.org/index.php/mjhid/article/view/174 |
work_keys_str_mv |
AT lucalaurenti allogeneictransplantationforchroniclymphocyticleukemia AT michelatarnani allogeneictransplantationforchroniclymphocyticleukemia AT patriziachiusolo allogeneictransplantationforchroniclymphocyticleukemia AT federicasora allogeneictransplantationforchroniclymphocyticleukemia AT simonasica allogeneictransplantationforchroniclymphocyticleukemia |
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