Network Walking charts transcriptional dynamics of nitrogen signaling by integrating validated and predicted genome-wide interactions

Temporal control of transcriptional networks enables organisms to adapt to changing environment. Here, the authors use a scaled-up cell-based assay to identify direct targets of nitrogen-early responsive transcription factors and validate a network path mediating dynamic nitrogen signaling in Arabid...

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Main Authors: Matthew D. Brooks, Jacopo Cirrone, Angelo V. Pasquino, Jose M. Alvarez, Joseph Swift, Shipra Mittal, Che-Lun Juang, Kranthi Varala, Rodrigo A. Gutiérrez, Gabriel Krouk, Dennis Shasha, Gloria M. Coruzzi
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09522-1
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spelling doaj-8373c4440151476f9e29c51167aed1f32021-05-11T11:48:53ZengNature Publishing GroupNature Communications2041-17232019-04-0110111310.1038/s41467-019-09522-1Network Walking charts transcriptional dynamics of nitrogen signaling by integrating validated and predicted genome-wide interactionsMatthew D. Brooks0Jacopo Cirrone1Angelo V. Pasquino2Jose M. Alvarez3Joseph Swift4Shipra Mittal5Che-Lun Juang6Kranthi Varala7Rodrigo A. Gutiérrez8Gabriel Krouk9Dennis Shasha10Gloria M. Coruzzi11Center for Genomics and Systems Biology, Department of Biology, New York UniversityCourant Institute for Mathematical Sciences, New York UniversityCenter for Genomics and Systems Biology, Department of Biology, New York UniversityCenter for Genomics and Systems Biology, Department of Biology, New York UniversityCenter for Genomics and Systems Biology, Department of Biology, New York UniversityCenter for Genomics and Systems Biology, Department of Biology, New York UniversityCenter for Genomics and Systems Biology, Department of Biology, New York UniversityHorticulture and Landscape Architecture/Center for Plant Biology, Purdue UniversityDepartamento de Genética Molecular y Microbiología, FONDAP Center for Genome Regulation, Millennium Institute for Integrative Biology, Pontificia Universidad Católica de ChileB&PMP, CNRS, INRA, Université de Montpellier, Montpellier SupAgroCourant Institute for Mathematical Sciences, New York UniversityCenter for Genomics and Systems Biology, Department of Biology, New York UniversityTemporal control of transcriptional networks enables organisms to adapt to changing environment. Here, the authors use a scaled-up cell-based assay to identify direct targets of nitrogen-early responsive transcription factors and validate a network path mediating dynamic nitrogen signaling in Arabidopsis.https://doi.org/10.1038/s41467-019-09522-1
collection DOAJ
language English
format Article
sources DOAJ
author Matthew D. Brooks
Jacopo Cirrone
Angelo V. Pasquino
Jose M. Alvarez
Joseph Swift
Shipra Mittal
Che-Lun Juang
Kranthi Varala
Rodrigo A. Gutiérrez
Gabriel Krouk
Dennis Shasha
Gloria M. Coruzzi
spellingShingle Matthew D. Brooks
Jacopo Cirrone
Angelo V. Pasquino
Jose M. Alvarez
Joseph Swift
Shipra Mittal
Che-Lun Juang
Kranthi Varala
Rodrigo A. Gutiérrez
Gabriel Krouk
Dennis Shasha
Gloria M. Coruzzi
Network Walking charts transcriptional dynamics of nitrogen signaling by integrating validated and predicted genome-wide interactions
Nature Communications
author_facet Matthew D. Brooks
Jacopo Cirrone
Angelo V. Pasquino
Jose M. Alvarez
Joseph Swift
Shipra Mittal
Che-Lun Juang
Kranthi Varala
Rodrigo A. Gutiérrez
Gabriel Krouk
Dennis Shasha
Gloria M. Coruzzi
author_sort Matthew D. Brooks
title Network Walking charts transcriptional dynamics of nitrogen signaling by integrating validated and predicted genome-wide interactions
title_short Network Walking charts transcriptional dynamics of nitrogen signaling by integrating validated and predicted genome-wide interactions
title_full Network Walking charts transcriptional dynamics of nitrogen signaling by integrating validated and predicted genome-wide interactions
title_fullStr Network Walking charts transcriptional dynamics of nitrogen signaling by integrating validated and predicted genome-wide interactions
title_full_unstemmed Network Walking charts transcriptional dynamics of nitrogen signaling by integrating validated and predicted genome-wide interactions
title_sort network walking charts transcriptional dynamics of nitrogen signaling by integrating validated and predicted genome-wide interactions
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-04-01
description Temporal control of transcriptional networks enables organisms to adapt to changing environment. Here, the authors use a scaled-up cell-based assay to identify direct targets of nitrogen-early responsive transcription factors and validate a network path mediating dynamic nitrogen signaling in Arabidopsis.
url https://doi.org/10.1038/s41467-019-09522-1
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