Chromatin Remodeling in the Brain-a <i>NuRD</i>evelopmental Odyssey

During brain development, the genome must be repeatedly reconfigured in order to facilitate neuronal and glial differentiation. A host of chromatin remodeling complexes facilitates this process. At the genetic level, the non-redundancy of these complexes suggests that neurodevelopment may require a...

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Main Authors:	Sarah Larrigan, Sujay Shah, Alex Fernandes, Pierre Mattar
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	International Journal of Molecular Sciences
Subjects:	NuRD neurodevelopment neurogenesis gliogenesis intellectual disability autism spectrum disorder
Online Access:	https://www.mdpi.com/1422-0067/22/9/4768

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spelling	doaj-8378371dc27c48fcb097c536ca7af62b2021-04-30T23:03:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01224768476810.3390/ijms22094768Chromatin Remodeling in the Brain-a <i>NuRD</i>evelopmental OdysseySarah Larrigan0Sujay Shah1Alex Fernandes2Pierre Mattar3Department of Cell and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDepartment of Cell and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDepartment of Cell and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDepartment of Cell and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDuring brain development, the genome must be repeatedly reconfigured in order to facilitate neuronal and glial differentiation. A host of chromatin remodeling complexes facilitates this process. At the genetic level, the non-redundancy of these complexes suggests that neurodevelopment may require a lexicon of remodelers with different specificities and activities. Here, we focus on the nucleosome remodeling and deacetylase (NuRD) complex. We review NuRD biochemistry, genetics, and functions in neural progenitors and neurons.https://www.mdpi.com/1422-0067/22/9/4768NuRDneurodevelopmentneurogenesisgliogenesisintellectual disabilityautism spectrum disorder
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sarah Larrigan Sujay Shah Alex Fernandes Pierre Mattar
spellingShingle	Sarah Larrigan Sujay Shah Alex Fernandes Pierre Mattar Chromatin Remodeling in the Brain-a <i>NuRD</i>evelopmental Odyssey International Journal of Molecular Sciences NuRD neurodevelopment neurogenesis gliogenesis intellectual disability autism spectrum disorder
author_facet	Sarah Larrigan Sujay Shah Alex Fernandes Pierre Mattar
author_sort	Sarah Larrigan
title	Chromatin Remodeling in the Brain-a <i>NuRD</i>evelopmental Odyssey
title_short	Chromatin Remodeling in the Brain-a <i>NuRD</i>evelopmental Odyssey
title_full	Chromatin Remodeling in the Brain-a <i>NuRD</i>evelopmental Odyssey
title_fullStr	Chromatin Remodeling in the Brain-a <i>NuRD</i>evelopmental Odyssey
title_full_unstemmed	Chromatin Remodeling in the Brain-a <i>NuRD</i>evelopmental Odyssey
title_sort	chromatin remodeling in the brain-a <i>nurd</i>evelopmental odyssey
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1661-6596 1422-0067
publishDate	2021-04-01
description	During brain development, the genome must be repeatedly reconfigured in order to facilitate neuronal and glial differentiation. A host of chromatin remodeling complexes facilitates this process. At the genetic level, the non-redundancy of these complexes suggests that neurodevelopment may require a lexicon of remodelers with different specificities and activities. Here, we focus on the nucleosome remodeling and deacetylase (NuRD) complex. We review NuRD biochemistry, genetics, and functions in neural progenitors and neurons.
topic	NuRD neurodevelopment neurogenesis gliogenesis intellectual disability autism spectrum disorder
url	https://www.mdpi.com/1422-0067/22/9/4768
work_keys_str_mv	AT sarahlarrigan chromatinremodelinginthebrainainurdievelopmentalodyssey AT sujayshah chromatinremodelinginthebrainainurdievelopmentalodyssey AT alexfernandes chromatinremodelinginthebrainainurdievelopmentalodyssey AT pierremattar chromatinremodelinginthebrainainurdievelopmentalodyssey
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Chromatin Remodeling in the Brain-a <i>NuRD</i>evelopmental Odyssey

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