Tauroursodeoxycholic acid alleviates pulmonary endoplasmic reticulum stress and epithelial-mesenchymal transition in bleomycin-induced lung fibrosis

Tauroursodeoxycholic acid alleviates pulmonary endoplasmic reticulum stress and epithelial-mesenchymal transition in bleomycin-induced lung fibrosis

Abstract Background Several studies demonstrate that endoplasmic reticulum (ER) stress-mediated epithelial-mesenchymal transition (EMT) is involved in the process of bleomycin (BLM)-induced pulmonary fibrosis. Tauroursodeoxycholic acid (TUDCA), a bile acid with chaperone properties, is an inhibitor...

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Bibliographic Details
Main Authors: Bin Tong, Lin Fu, Biao Hu, Zhi-Cheng Zhang, Zhu-Xia Tan, Se-Ruo Li, Yuan-Hua Chen, Cheng Zhang, Hua Wang, De-Xiang Xu, Hui Zhao
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Pulmonary Medicine
Subjects:
Idiopathic pulmonary fibrosis
Tauroursodeoxycholic acid
Epithelial-mesenchymal transition
Endoplasmic reticulum stress
Oxidative stress
Online Access:https://doi.org/10.1186/s12890-021-01514-6

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