Aberrations of Genomic Imprinting in Glioblastoma Formation
In human glioblastoma (GBM), the presence of a small population of cells with stem cell characteristics, the glioma stem cells (GSCs), has been described. These cells have GBM potential and are responsible for the origin of the tumors. However, whether GSCs originate from normal neural stem cells (N...
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doaj-837ff70ac14a448891d86c0a6dd2c7382021-03-12T07:48:44ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.630482630482Aberrations of Genomic Imprinting in Glioblastoma FormationAnna Lozano-Ureña0Anna Lozano-Ureña1Esteban Jiménez-Villalba2Alejandro Pinedo-Serrano3Antonio Jordán-Pla4Martina Kirstein5Martina Kirstein6Sacri R. Ferrón7Sacri R. Ferrón8Instituto de Biotecnología y Biomedicina (BIOTECMED), Valencia, SpainDepartamento de Biología Celular, Universidad de Valencia, Valencia, SpainInstituto de Biotecnología y Biomedicina (BIOTECMED), Valencia, SpainInstituto de Biotecnología y Biomedicina (BIOTECMED), Valencia, SpainInstituto de Biotecnología y Biomedicina (BIOTECMED), Valencia, SpainInstituto de Biotecnología y Biomedicina (BIOTECMED), Valencia, SpainDepartamento de Biología Celular, Universidad de Valencia, Valencia, SpainInstituto de Biotecnología y Biomedicina (BIOTECMED), Valencia, SpainDepartamento de Biología Celular, Universidad de Valencia, Valencia, SpainIn human glioblastoma (GBM), the presence of a small population of cells with stem cell characteristics, the glioma stem cells (GSCs), has been described. These cells have GBM potential and are responsible for the origin of the tumors. However, whether GSCs originate from normal neural stem cells (NSCs) as a consequence of genetic and epigenetic changes and/or dedifferentiation from somatic cells remains to be investigated. Genomic imprinting is an epigenetic marking process that causes genes to be expressed depending on their parental origin. The dysregulation of the imprinting pattern or the loss of genomic imprinting (LOI) have been described in different tumors including GBM, being one of the earliest and most common events that occurs in human cancers. Here we have gathered the current knowledge of the role of imprinted genes in normal NSCs function and how the imprinting process is altered in human GBM. We also review the changes at particular imprinted loci that might be involved in the development of the tumor. Understanding the mechanistic similarities in the regulation of genomic imprinting between normal NSCs and GBM cells will be helpful to identify molecular players that might be involved in the development of human GBM.https://www.frontiersin.org/articles/10.3389/fonc.2021.630482/fullgenomic imprintingglioblastomaneural stem cellsmethylationsubventricular zone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna Lozano-Ureña Anna Lozano-Ureña Esteban Jiménez-Villalba Alejandro Pinedo-Serrano Antonio Jordán-Pla Martina Kirstein Martina Kirstein Sacri R. Ferrón Sacri R. Ferrón |
spellingShingle |
Anna Lozano-Ureña Anna Lozano-Ureña Esteban Jiménez-Villalba Alejandro Pinedo-Serrano Antonio Jordán-Pla Martina Kirstein Martina Kirstein Sacri R. Ferrón Sacri R. Ferrón Aberrations of Genomic Imprinting in Glioblastoma Formation Frontiers in Oncology genomic imprinting glioblastoma neural stem cells methylation subventricular zone |
author_facet |
Anna Lozano-Ureña Anna Lozano-Ureña Esteban Jiménez-Villalba Alejandro Pinedo-Serrano Antonio Jordán-Pla Martina Kirstein Martina Kirstein Sacri R. Ferrón Sacri R. Ferrón |
author_sort |
Anna Lozano-Ureña |
title |
Aberrations of Genomic Imprinting in Glioblastoma Formation |
title_short |
Aberrations of Genomic Imprinting in Glioblastoma Formation |
title_full |
Aberrations of Genomic Imprinting in Glioblastoma Formation |
title_fullStr |
Aberrations of Genomic Imprinting in Glioblastoma Formation |
title_full_unstemmed |
Aberrations of Genomic Imprinting in Glioblastoma Formation |
title_sort |
aberrations of genomic imprinting in glioblastoma formation |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-03-01 |
description |
In human glioblastoma (GBM), the presence of a small population of cells with stem cell characteristics, the glioma stem cells (GSCs), has been described. These cells have GBM potential and are responsible for the origin of the tumors. However, whether GSCs originate from normal neural stem cells (NSCs) as a consequence of genetic and epigenetic changes and/or dedifferentiation from somatic cells remains to be investigated. Genomic imprinting is an epigenetic marking process that causes genes to be expressed depending on their parental origin. The dysregulation of the imprinting pattern or the loss of genomic imprinting (LOI) have been described in different tumors including GBM, being one of the earliest and most common events that occurs in human cancers. Here we have gathered the current knowledge of the role of imprinted genes in normal NSCs function and how the imprinting process is altered in human GBM. We also review the changes at particular imprinted loci that might be involved in the development of the tumor. Understanding the mechanistic similarities in the regulation of genomic imprinting between normal NSCs and GBM cells will be helpful to identify molecular players that might be involved in the development of human GBM. |
topic |
genomic imprinting glioblastoma neural stem cells methylation subventricular zone |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.630482/full |
work_keys_str_mv |
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