Superoxide dismutase in Cryptococcus neoformans varieties gattii, grubi, and neoformans

• Main Authors: ALT Dias, MRPL Brigagão, P Colepicolo, AM Siqueira, EG da Silva, CR Paula
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 2006-02-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: Cryptococcus neoformans; superoxide dismutase; antioxidant
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000100021

Some clear dissimilarities occur among the varieties of Cryptococcus neoformans but there are few studies about the differences among individual yeast antioxidant enzymes. The total superoxide dismutase (SOD) activities and the copper, zinc-depend SOD (Cu,ZnSOD) and manganese-dependent SOD (MnSOD) isoenzymes of five reference C. neoformans strains belonged to A, B, C, AD and D serotypes (<A HREF="/img/revistas/mioc/v101n1/a21t1.jpg">Table I</A>) and other nine C. neoformans isolates (<A HREF="/img/revistas/mioc/v101n1/a21t2.jpg">Table II</A>) were determined. There were significant differences (p < 0.01 and p < 0.05) in total SOD activity among the varietie gattii (serotype C) and the other varieties. Cu,ZnSOD showed difference (p < 0.05) between A and D serotypes. These results point out a variety and serotype-independent SOD activity in C. neoformans reference strains and the other isolates that were evaluated.