Cell-Free DNA in Rheumatoid Arthritis
Endogenous DNA derived from the nuclei or mitochondria is released into the bloodstream following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is associated with various pathological conditions. Recently, multiple aspects of cfDNA have been assessed, including cfDNA levels,...
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doaj-83964662f0dd4b0aba26bd36d534c0c22021-08-26T13:53:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-01228941894110.3390/ijms22168941Cell-Free DNA in Rheumatoid ArthritisTeppei Hashimoto0Kohsuke Yoshida1Akira Hashiramoto2Kiyoshi Matsui3Division of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya 6638501, JapanDepartment of Biophysics, Kobe University Graduate School of Health Sciences, Kobe 6540142, JapanDepartment of Biophysics, Kobe University Graduate School of Health Sciences, Kobe 6540142, JapanDivision of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya 6638501, JapanEndogenous DNA derived from the nuclei or mitochondria is released into the bloodstream following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is associated with various pathological conditions. Recently, multiple aspects of cfDNA have been assessed, including cfDNA levels, integrity, methylation, and mutations. Rheumatoid arthritis (RA) is the most common form of autoimmune arthritis, and treatment of RA has highly varied outcomes. cfDNA in patients with RA is elevated in peripheral blood and synovial fluid and is associated with disease activity. Profiling of cfDNA in patients with RA may then be utilized in various aspects of clinical practice, such as the prediction of prognosis and treatment responses; monitoring disease state; and as a diagnostic marker. In this review, we discuss cfDNA in patients with RA, particularly the sources of cfDNA and the correlation of cfDNA with RA pathogenesis. We also highlight the potential of analyzing cfDNA profiles to guide individualized treatment approaches for RA.https://www.mdpi.com/1422-0067/22/16/8941biomarkercell-free DNArheumatoid arthritisprecision medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Teppei Hashimoto Kohsuke Yoshida Akira Hashiramoto Kiyoshi Matsui |
spellingShingle |
Teppei Hashimoto Kohsuke Yoshida Akira Hashiramoto Kiyoshi Matsui Cell-Free DNA in Rheumatoid Arthritis International Journal of Molecular Sciences biomarker cell-free DNA rheumatoid arthritis precision medicine |
author_facet |
Teppei Hashimoto Kohsuke Yoshida Akira Hashiramoto Kiyoshi Matsui |
author_sort |
Teppei Hashimoto |
title |
Cell-Free DNA in Rheumatoid Arthritis |
title_short |
Cell-Free DNA in Rheumatoid Arthritis |
title_full |
Cell-Free DNA in Rheumatoid Arthritis |
title_fullStr |
Cell-Free DNA in Rheumatoid Arthritis |
title_full_unstemmed |
Cell-Free DNA in Rheumatoid Arthritis |
title_sort |
cell-free dna in rheumatoid arthritis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-08-01 |
description |
Endogenous DNA derived from the nuclei or mitochondria is released into the bloodstream following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is associated with various pathological conditions. Recently, multiple aspects of cfDNA have been assessed, including cfDNA levels, integrity, methylation, and mutations. Rheumatoid arthritis (RA) is the most common form of autoimmune arthritis, and treatment of RA has highly varied outcomes. cfDNA in patients with RA is elevated in peripheral blood and synovial fluid and is associated with disease activity. Profiling of cfDNA in patients with RA may then be utilized in various aspects of clinical practice, such as the prediction of prognosis and treatment responses; monitoring disease state; and as a diagnostic marker. In this review, we discuss cfDNA in patients with RA, particularly the sources of cfDNA and the correlation of cfDNA with RA pathogenesis. We also highlight the potential of analyzing cfDNA profiles to guide individualized treatment approaches for RA. |
topic |
biomarker cell-free DNA rheumatoid arthritis precision medicine |
url |
https://www.mdpi.com/1422-0067/22/16/8941 |
work_keys_str_mv |
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1721192494796898304 |