The Relationship Between Obesity, Insulin Resistance, and Conjunctival Impression Cytology
Objective: This study was designed to determine whether obesity causes the development of metaplasia in conjunctival epithelial cells. Material and Method: A total of 61 volunteer participants who had no previous history of illness or drug use were involved in this study. Of those, 20 were obese, a...
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Federation of Turkish Pathology Societies
2019-05-01
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doaj-839f5c31b6254381915a66fffbdff3cf2020-11-24T20:40:21ZengFederation of Turkish Pathology SocietiesTürk Patoloji Dergisi1018-56151309-57302019-05-0135211912710.5146/tjpath.2018.01451The Relationship Between Obesity, Insulin Resistance, and Conjunctival Impression CytologyMurat DAĞDEVIRENMustafa ALTAYZennure YILDIZGülçin ŞIMŞEKMehmet ÇITIRIKİhsan ATEŞTanyel Sema DAĞDEVIRENCanan YILDIZTuğba ŞAHINObjective: This study was designed to determine whether obesity causes the development of metaplasia in conjunctival epithelial cells. Material and Method: A total of 61 volunteer participants who had no previous history of illness or drug use were involved in this study. Of those, 20 were obese, and 41 were of normal weight. We measured the glucose and insulin values of all volunteers. We also measured the Body Mass Index (BMI) and Homeostasis Model Assessment for Insulin Resistance (HOMA IR). The impression cytology method was used to analyze the conjunctival epithelium cells, and to classify them between Grades 0 to 3 according to the Nelson criteria. Results: There was a certain level of loss of goblet cells on the 90% level as well as squamous metaplasia (Grade 2-3) in 80% of the obese participants and impression cytology was found to be normal in only two patients. The expected results were observed in 56.1% of the control group where the squamous metaplasia rate was nearly 17% (p<0.001). 90.9% of the grade 3 patients were obese. The variables as independent predictors were found to indicate the existence of abnormal cytology in the conjunctiva at various levels; BMI (OR: 1.24; p=0.002) and HOMA IR (OR= 28.6; p= 0.001) in a Model I multivariable regression model, and the existence of obesity (OR: 11.91; p=0.002) and HOMA IR (OR= 15.08; p<0.001) in a Model II multivariable regression model. Conclusion: Obesity was found to be a disorder that causes metaplasia in the conjunctival epithelium cells for the first time. http://www.turkjpath.org/pdf.php3?id=1888 ConjunctivaImpression cytologyInflammationObesity |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Murat DAĞDEVIREN Mustafa ALTAY Zennure YILDIZ Gülçin ŞIMŞEK Mehmet ÇITIRIK İhsan ATEŞ Tanyel Sema DAĞDEVIREN Canan YILDIZ Tuğba ŞAHIN |
spellingShingle |
Murat DAĞDEVIREN Mustafa ALTAY Zennure YILDIZ Gülçin ŞIMŞEK Mehmet ÇITIRIK İhsan ATEŞ Tanyel Sema DAĞDEVIREN Canan YILDIZ Tuğba ŞAHIN The Relationship Between Obesity, Insulin Resistance, and Conjunctival Impression Cytology Türk Patoloji Dergisi Conjunctiva Impression cytology Inflammation Obesity |
author_facet |
Murat DAĞDEVIREN Mustafa ALTAY Zennure YILDIZ Gülçin ŞIMŞEK Mehmet ÇITIRIK İhsan ATEŞ Tanyel Sema DAĞDEVIREN Canan YILDIZ Tuğba ŞAHIN |
author_sort |
Murat DAĞDEVIREN |
title |
The Relationship Between Obesity, Insulin Resistance, and Conjunctival Impression Cytology |
title_short |
The Relationship Between Obesity, Insulin Resistance, and Conjunctival Impression Cytology |
title_full |
The Relationship Between Obesity, Insulin Resistance, and Conjunctival Impression Cytology |
title_fullStr |
The Relationship Between Obesity, Insulin Resistance, and Conjunctival Impression Cytology |
title_full_unstemmed |
The Relationship Between Obesity, Insulin Resistance, and Conjunctival Impression Cytology |
title_sort |
relationship between obesity, insulin resistance, and conjunctival impression cytology |
publisher |
Federation of Turkish Pathology Societies |
series |
Türk Patoloji Dergisi |
issn |
1018-5615 1309-5730 |
publishDate |
2019-05-01 |
description |
Objective: This study was designed to determine whether obesity causes the development of metaplasia in conjunctival epithelial cells.
Material and Method: A total of 61 volunteer participants who had no previous history of illness or drug use were involved in this study. Of those, 20 were obese, and 41 were of normal weight. We measured the glucose and insulin values of all volunteers. We also measured the Body Mass Index (BMI) and Homeostasis Model Assessment for Insulin Resistance (HOMA IR). The impression cytology method was used to analyze the conjunctival epithelium cells, and to classify them between Grades 0 to 3 according to the Nelson criteria.
Results: There was a certain level of loss of goblet cells on the 90% level as well as squamous metaplasia (Grade 2-3) in 80% of the obese participants and impression cytology was found to be normal in only two patients. The expected results were observed in 56.1% of the control group where the squamous metaplasia rate was nearly 17% (p<0.001). 90.9% of the grade 3 patients were obese. The variables as independent predictors were found to indicate the existence of abnormal cytology in the conjunctiva at various levels; BMI (OR: 1.24; p=0.002) and HOMA IR (OR= 28.6; p= 0.001) in a Model I multivariable regression model, and the existence of obesity (OR: 11.91; p=0.002) and HOMA IR (OR= 15.08; p<0.001) in a Model II multivariable regression model.
Conclusion: Obesity was found to be a disorder that causes metaplasia in the conjunctival epithelium cells for the first time. |
topic |
Conjunctiva Impression cytology Inflammation Obesity |
url |
http://www.turkjpath.org/pdf.php3?id=1888
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