The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease
Inflammatory bowel disease (IBD), with major manifestations as Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic intestinal inflammatory disorder with an unknown etiology which pathogensis involving multifactorial immune disorder characterized by chronic relapsing inflammation of the in...
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2017-12-01
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doaj-83a632b1cdc44c3899ab93ba50124d502020-11-25T01:10:52ZengInterna PublishingThe Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy1411-48012302-81812017-12-01183184196https://doi.org/10.24871/1832017184-196The Role of Biologics Agent in the Treatment of Inflammatory Bowel DiseaseTri Hapsoro GunoMarcellus SimadibrataInflammatory bowel disease (IBD), with major manifestations as Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic intestinal inflammatory disorder with an unknown etiology which pathogensis involving multifactorial immune disorder characterized by chronic relapsing inflammation of the intestine. Management of IBD depends on stage and location of the inflammation consist of the classic conventional treatment and the more new treatment with biologics agent. Biologics agent refers to monoclonal antibodies with activity directed against specific targets involved in the pathogenesis of chronic inflammatory conditions. Advances in the understanding of the specific mechanisms of pathogenesis IBD led to the development of targeted treatment. Today there are six biologics agent approved and used as therapy and there still many other biologics agent on research progress. Many reports show positive report about efficacy for the biological therapy compared with placebo and conventional treatment for the IBD. Limited by their cost and adverse effect that possibly happened, biologics agent is still promising therapy that change the course of IBD treatment.http://ina-jghe.com/journal/index.php/jghe/article/view/642/515Inflammatory bowel disease (IBD); Crohn’s disease (CD)ulcerative colitis (UC)biological therapybiologics agenInflammatory bowel disease (IBD)Crohn’s disease (CD) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tri Hapsoro Guno Marcellus Simadibrata |
spellingShingle |
Tri Hapsoro Guno Marcellus Simadibrata The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Inflammatory bowel disease (IBD); Crohn’s disease (CD) ulcerative colitis (UC) biological therapy biologics agen Inflammatory bowel disease (IBD) Crohn’s disease (CD) |
author_facet |
Tri Hapsoro Guno Marcellus Simadibrata |
author_sort |
Tri Hapsoro Guno |
title |
The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease |
title_short |
The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease |
title_full |
The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease |
title_fullStr |
The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease |
title_full_unstemmed |
The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease |
title_sort |
role of biologics agent in the treatment of inflammatory bowel disease |
publisher |
Interna Publishing |
series |
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
issn |
1411-4801 2302-8181 |
publishDate |
2017-12-01 |
description |
Inflammatory bowel disease (IBD), with major manifestations as Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic intestinal inflammatory disorder with an unknown etiology which pathogensis involving multifactorial immune disorder characterized by chronic relapsing inflammation of the intestine. Management of IBD depends on stage and location of the inflammation consist of the classic conventional treatment and the more new treatment with biologics agent. Biologics agent refers to monoclonal antibodies with activity directed against specific targets involved in the pathogenesis of chronic inflammatory conditions. Advances in the understanding of the specific mechanisms of pathogenesis IBD led to the development of targeted treatment. Today there are six biologics agent approved and used as therapy and there still many other biologics agent on research progress. Many reports show positive report about efficacy for the biological therapy compared with placebo and conventional treatment for the IBD. Limited by their cost and adverse effect that possibly happened, biologics agent is still promising therapy that change the course of IBD treatment. |
topic |
Inflammatory bowel disease (IBD); Crohn’s disease (CD) ulcerative colitis (UC) biological therapy biologics agen Inflammatory bowel disease (IBD) Crohn’s disease (CD) |
url |
http://ina-jghe.com/journal/index.php/jghe/article/view/642/515 |
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