Cholesterol Metabolism in T Cells
Compartmentalization and spatial control of biochemical reactions is the foundation of cell-based life on earth. The lipid bilayer system employed by eukaryote cells not only keeps them separate from the environment but also provides a platform for key receptors to sense and interact with outside fa...
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doaj-83ae3bc7782a4c7785723375728964f52020-11-24T23:14:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-11-01810.3389/fimmu.2017.01664316148Cholesterol Metabolism in T CellsAndreas Bietz0Andreas Bietz1Hengyu Zhu2Manman Xue3Chenqi Xu4Chenqi Xu5State Key Laboratory of Molecular Biology, Chinese Academy Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, ChinaUniversity of Heidelberg, Heidelberg, GermanyState Key Laboratory of Molecular Biology, Chinese Academy Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, ChinaState Key Laboratory of Molecular Biology, Chinese Academy Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, ChinaState Key Laboratory of Molecular Biology, Chinese Academy Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, ChinaSchool of Life Science and Technology, ShanghaiTech University, Shanghai, ChinaCompartmentalization and spatial control of biochemical reactions is the foundation of cell-based life on earth. The lipid bilayer system employed by eukaryote cells not only keeps them separate from the environment but also provides a platform for key receptors to sense and interact with outside factors. Arguably one of the cell types most reliant on interactions of this kind, immune cells depend on their membrane to keep functioning properly. In this review, the influence of variation in cholesterol levels, a key component of lipid bilayer stability, on T cells will be discussed in detail. In comparison to other cells, T cells must be able to undergo rapid activation followed by proliferation. Furthermore, receptor colocalization is an important mechanism in this activation process. The impact of cholesterol availability on the processes of T cell proliferation and receptor sensitivity, as well as its potential for immunomodulation in disease treatment will be considered.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01664/fullcholesterolmetabolismT celldiseaseimmunomodulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andreas Bietz Andreas Bietz Hengyu Zhu Manman Xue Chenqi Xu Chenqi Xu |
spellingShingle |
Andreas Bietz Andreas Bietz Hengyu Zhu Manman Xue Chenqi Xu Chenqi Xu Cholesterol Metabolism in T Cells Frontiers in Immunology cholesterol metabolism T cell disease immunomodulation |
author_facet |
Andreas Bietz Andreas Bietz Hengyu Zhu Manman Xue Chenqi Xu Chenqi Xu |
author_sort |
Andreas Bietz |
title |
Cholesterol Metabolism in T Cells |
title_short |
Cholesterol Metabolism in T Cells |
title_full |
Cholesterol Metabolism in T Cells |
title_fullStr |
Cholesterol Metabolism in T Cells |
title_full_unstemmed |
Cholesterol Metabolism in T Cells |
title_sort |
cholesterol metabolism in t cells |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2017-11-01 |
description |
Compartmentalization and spatial control of biochemical reactions is the foundation of cell-based life on earth. The lipid bilayer system employed by eukaryote cells not only keeps them separate from the environment but also provides a platform for key receptors to sense and interact with outside factors. Arguably one of the cell types most reliant on interactions of this kind, immune cells depend on their membrane to keep functioning properly. In this review, the influence of variation in cholesterol levels, a key component of lipid bilayer stability, on T cells will be discussed in detail. In comparison to other cells, T cells must be able to undergo rapid activation followed by proliferation. Furthermore, receptor colocalization is an important mechanism in this activation process. The impact of cholesterol availability on the processes of T cell proliferation and receptor sensitivity, as well as its potential for immunomodulation in disease treatment will be considered. |
topic |
cholesterol metabolism T cell disease immunomodulation |
url |
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01664/full |
work_keys_str_mv |
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1725594740623147008 |