The ethical challenges raised in the design and conduct of pragmatic trials: an interview study with key stakeholders

The ethical challenges raised in the design and conduct of pragmatic trials: an interview study with key stakeholders

Abstract Background There is a concern that the apparent effectiveness of interventions tested in clinical trials may not be an accurate reflection of their actual effectiveness in usual practice. Pragmatic randomized controlled trials (RCTs) are designed with the intent of addressing this discrepan...

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Main Authors: Stuart G. Nicholls, Kelly Carroll, Merrick Zwarenstein, Jamie C. Brehaut, Charles Weijer, Spencer P. Hey, Cory E. Goldstein, Ian D. Graham, Jeremy M. Grimshaw, Joanne E. McKenzie, Dean A. Fergusson, Monica Taljaard, on behalf of the Ethics of Pragmatic Trials project
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Trials
Subjects:
Pragmatic trial
Randomized controlled trial
Comparative effectiveness
Research ethics
Informed consent
Benefit-harm analysis
Online Access:https://doi.org/10.1186/s13063-019-3899-x

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