Immune Imbalance in Nasal Polyps of Caucasian Chronic Rhinosinusitis Patients Is Associated with a Downregulation of E-Selectin
Chronic rhinosinusitis with nasal polyps (CRSwNP) in Caucasians is a chronic Th2 inflammatory disease of the nasal and paranasal mucosa and the recruitment of leukocytes to the site of inflammation is poorly understood. We studied mRNA and protein expression profiles of adhesion molecules in nasal p...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2014-01-01
|
Series: | Journal of Immunology Research |
Online Access: | http://dx.doi.org/10.1155/2014/959854 |
id |
doaj-83be97867d6e4fa68465a70f57510659 |
---|---|
record_format |
Article |
spelling |
doaj-83be97867d6e4fa68465a70f575106592020-11-24T22:05:27ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/959854959854Immune Imbalance in Nasal Polyps of Caucasian Chronic Rhinosinusitis Patients Is Associated with a Downregulation of E-SelectinMichael Könnecke0Robert Böscke1Anja Waldmann2Karl-Ludwig Bruchhage3Robert Linke4Ralph Pries5Barbara Wollenberg6Department of Otorhinolaryngology, University Medical Center Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, Luebeck, GermanyDepartment of Otorhinolaryngology, University Medical Center Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, Luebeck, GermanyDepartment of Otorhinolaryngology, University Medical Center Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, Luebeck, GermanyDepartment of Otorhinolaryngology, University Medical Center Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, Luebeck, GermanyDepartment of Otorhinolaryngology, University Medical Center Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, Luebeck, GermanyDepartment of Otorhinolaryngology, University Medical Center Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, Luebeck, GermanyDepartment of Otorhinolaryngology, University Medical Center Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, Luebeck, GermanyChronic rhinosinusitis with nasal polyps (CRSwNP) in Caucasians is a chronic Th2 inflammatory disease of the nasal and paranasal mucosa and the recruitment of leukocytes to the site of inflammation is poorly understood. We studied mRNA and protein expression profiles of adhesion molecules in nasal polyp and associated inferior turbinate tissues using molecular, biochemical, and immunohistological methods. Analysis showed a strongly decreased E-selectin expression in nasal polyps with a significant difference between eosinophil and neutrophil counts in nasal polyps and balanced counts in inferior turbinates. E-selectin expression is known to be downregulated in a Th2 milieu and has an essential role in immunosurveillance by locally activating neutrophil arrest and migratory function. A downregulation of E-selectin may come along with an immune imbalance in Caucasian nasal polyps due to a significant inhibition of neutrophil recruitment. Therefore, we suggest that an upregulation of E-selectin and the associated influx of neutrophils may play a significant role in the resolution of inflammation as well as for the pathophysiology of nasal polyps of Caucasian chronic rhinosinusitis patients.http://dx.doi.org/10.1155/2014/959854 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael Könnecke Robert Böscke Anja Waldmann Karl-Ludwig Bruchhage Robert Linke Ralph Pries Barbara Wollenberg |
spellingShingle |
Michael Könnecke Robert Böscke Anja Waldmann Karl-Ludwig Bruchhage Robert Linke Ralph Pries Barbara Wollenberg Immune Imbalance in Nasal Polyps of Caucasian Chronic Rhinosinusitis Patients Is Associated with a Downregulation of E-Selectin Journal of Immunology Research |
author_facet |
Michael Könnecke Robert Böscke Anja Waldmann Karl-Ludwig Bruchhage Robert Linke Ralph Pries Barbara Wollenberg |
author_sort |
Michael Könnecke |
title |
Immune Imbalance in Nasal Polyps of Caucasian Chronic Rhinosinusitis Patients Is Associated with a Downregulation of E-Selectin |
title_short |
Immune Imbalance in Nasal Polyps of Caucasian Chronic Rhinosinusitis Patients Is Associated with a Downregulation of E-Selectin |
title_full |
Immune Imbalance in Nasal Polyps of Caucasian Chronic Rhinosinusitis Patients Is Associated with a Downregulation of E-Selectin |
title_fullStr |
Immune Imbalance in Nasal Polyps of Caucasian Chronic Rhinosinusitis Patients Is Associated with a Downregulation of E-Selectin |
title_full_unstemmed |
Immune Imbalance in Nasal Polyps of Caucasian Chronic Rhinosinusitis Patients Is Associated with a Downregulation of E-Selectin |
title_sort |
immune imbalance in nasal polyps of caucasian chronic rhinosinusitis patients is associated with a downregulation of e-selectin |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-8861 2314-7156 |
publishDate |
2014-01-01 |
description |
Chronic rhinosinusitis with nasal polyps (CRSwNP) in Caucasians is a chronic Th2 inflammatory disease of the nasal and paranasal mucosa and the recruitment of leukocytes to the site of inflammation is poorly understood. We studied mRNA and protein expression profiles of adhesion molecules in nasal polyp and associated inferior turbinate tissues using molecular, biochemical, and immunohistological methods. Analysis showed a strongly decreased E-selectin expression in nasal polyps with a significant difference between eosinophil and neutrophil counts in nasal polyps and balanced counts in inferior turbinates. E-selectin expression is known to be downregulated in a Th2 milieu and has an essential role in immunosurveillance by locally activating neutrophil arrest and migratory function. A downregulation of E-selectin may come along with an immune imbalance in Caucasian nasal polyps due to a significant inhibition of neutrophil recruitment. Therefore, we suggest that an upregulation of E-selectin and the associated influx of neutrophils may play a significant role in the resolution of inflammation as well as for the pathophysiology of nasal polyps of Caucasian chronic rhinosinusitis patients. |
url |
http://dx.doi.org/10.1155/2014/959854 |
work_keys_str_mv |
AT michaelkonnecke immuneimbalanceinnasalpolypsofcaucasianchronicrhinosinusitispatientsisassociatedwithadownregulationofeselectin AT robertboscke immuneimbalanceinnasalpolypsofcaucasianchronicrhinosinusitispatientsisassociatedwithadownregulationofeselectin AT anjawaldmann immuneimbalanceinnasalpolypsofcaucasianchronicrhinosinusitispatientsisassociatedwithadownregulationofeselectin AT karlludwigbruchhage immuneimbalanceinnasalpolypsofcaucasianchronicrhinosinusitispatientsisassociatedwithadownregulationofeselectin AT robertlinke immuneimbalanceinnasalpolypsofcaucasianchronicrhinosinusitispatientsisassociatedwithadownregulationofeselectin AT ralphpries immuneimbalanceinnasalpolypsofcaucasianchronicrhinosinusitispatientsisassociatedwithadownregulationofeselectin AT barbarawollenberg immuneimbalanceinnasalpolypsofcaucasianchronicrhinosinusitispatientsisassociatedwithadownregulationofeselectin |
_version_ |
1725826304476971008 |