Whole exome sequencing approach to childhood onset familial erythrodermic psoriasis unravels a novel mutation of CARD14 requiring unusual high doses of ustekinumab

Whole exome sequencing approach to childhood onset familial erythrodermic psoriasis unravels a novel mutation of CARD14 requiring unusual high doses of ustekinumab

Abstract Background Autosomal dominant gain of function mutations in caspase recruitment domain family member 14 (CARD14) is a rare condition associated with plaque-type psoriasis, generalized pustular psoriasis, palmoplantar pustular psoriasis and pityriasis rubra pilaris. Recently, a new CARD14 –a...

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Bibliographic Details
Main Authors: S. Signa, E. Campione, M. Rusmini, S. Chiesa, A. Grossi, A. Omenetti, R. Caorsi, G. M. Viglizzo, M. Galluzzo, L. Bianchi, M. Talamonti, A. Orlandi, A. Martini, I. Ceccherini, M. Gattorno
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Pediatric Rheumatology Online Journal
Subjects:
Erythrodermic psoriasis
CARD14
Ustekinumab
Whole exome sequencing
Online Access:http://link.springer.com/article/10.1186/s12969-019-0336-3

Internet

http://link.springer.com/article/10.1186/s12969-019-0336-3

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