Metabolism-related long non-coding RNAs (lncRNAs) as potential biomarkers for predicting risk of recurrence in breast cancer patients

Metabolism affects the development, progression, and prognosis of various cancers, including breast cancer (BC). Our aim was to develop a metabolism-related long non-coding RNA (lncRNA) signature to assess the prognosis of BC patients in order to optimize treatment. Metabolism-related genes between...

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Main Authors: Jian-ying Ma, Shao-hua Liu, Jie Chen, Qin Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Bioengineered
Subjects:
Online Access:http://dx.doi.org/10.1080/21655979.2021.1953216
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spelling doaj-83c44c7cdd9b48ddb777e9a44dd16d822021-08-09T18:41:15ZengTaylor & Francis GroupBioengineered2165-59792165-59872021-01-011213726373610.1080/21655979.2021.19532161953216Metabolism-related long non-coding RNAs (lncRNAs) as potential biomarkers for predicting risk of recurrence in breast cancer patientsJian-ying Ma0Shao-hua Liu1Jie Chen2Qin Liu3Huangshi Central Hospital of Edong Healthcare Group, Hubei Polytechnic UniversityHuangshi Central Hospital of Edong Healthcare Group, Hubei Polytechnic UniversityHuangshi Central Hospital of Edong Healthcare Group, Hubei Polytechnic UniversityHuangshi Central Hospital of Edong Healthcare Group, Hubei Polytechnic UniversityMetabolism affects the development, progression, and prognosis of various cancers, including breast cancer (BC). Our aim was to develop a metabolism-related long non-coding RNA (lncRNA) signature to assess the prognosis of BC patients in order to optimize treatment. Metabolism-related genes between breast tumors and normal tissues were screened out, and Pearson correlation analysis was used to investigate metabolism-related lncRNAs. In total, five metabolism-related lncRNAs were enrolled to establish prognostic signatures. Kaplan-Meier plots and the receiver operating characteristic (ROC) curves demonstrated good performance in both training and validation groups. Further analysis demonstrated that the signature was an independent prognostic factor for BC. A nomogram incorporating risk score and tumor stage was then constructed to evaluate the 3 – and 5-year recurrence-free survival (RFS) in patients with BC. In conclusion, this study identified a metabolism-related lncRNA signature that can predict RFS of BC patients and established a prognostic nomogram that helps guide the individualized treatment of patients at different risks.http://dx.doi.org/10.1080/21655979.2021.1953216breast cancermetabolismrecurrence-free survivalrisk score
collection DOAJ
language English
format Article
sources DOAJ
author Jian-ying Ma
Shao-hua Liu
Jie Chen
Qin Liu
spellingShingle Jian-ying Ma
Shao-hua Liu
Jie Chen
Qin Liu
Metabolism-related long non-coding RNAs (lncRNAs) as potential biomarkers for predicting risk of recurrence in breast cancer patients
Bioengineered
breast cancer
metabolism
recurrence-free survival
risk score
author_facet Jian-ying Ma
Shao-hua Liu
Jie Chen
Qin Liu
author_sort Jian-ying Ma
title Metabolism-related long non-coding RNAs (lncRNAs) as potential biomarkers for predicting risk of recurrence in breast cancer patients
title_short Metabolism-related long non-coding RNAs (lncRNAs) as potential biomarkers for predicting risk of recurrence in breast cancer patients
title_full Metabolism-related long non-coding RNAs (lncRNAs) as potential biomarkers for predicting risk of recurrence in breast cancer patients
title_fullStr Metabolism-related long non-coding RNAs (lncRNAs) as potential biomarkers for predicting risk of recurrence in breast cancer patients
title_full_unstemmed Metabolism-related long non-coding RNAs (lncRNAs) as potential biomarkers for predicting risk of recurrence in breast cancer patients
title_sort metabolism-related long non-coding rnas (lncrnas) as potential biomarkers for predicting risk of recurrence in breast cancer patients
publisher Taylor & Francis Group
series Bioengineered
issn 2165-5979
2165-5987
publishDate 2021-01-01
description Metabolism affects the development, progression, and prognosis of various cancers, including breast cancer (BC). Our aim was to develop a metabolism-related long non-coding RNA (lncRNA) signature to assess the prognosis of BC patients in order to optimize treatment. Metabolism-related genes between breast tumors and normal tissues were screened out, and Pearson correlation analysis was used to investigate metabolism-related lncRNAs. In total, five metabolism-related lncRNAs were enrolled to establish prognostic signatures. Kaplan-Meier plots and the receiver operating characteristic (ROC) curves demonstrated good performance in both training and validation groups. Further analysis demonstrated that the signature was an independent prognostic factor for BC. A nomogram incorporating risk score and tumor stage was then constructed to evaluate the 3 – and 5-year recurrence-free survival (RFS) in patients with BC. In conclusion, this study identified a metabolism-related lncRNA signature that can predict RFS of BC patients and established a prognostic nomogram that helps guide the individualized treatment of patients at different risks.
topic breast cancer
metabolism
recurrence-free survival
risk score
url http://dx.doi.org/10.1080/21655979.2021.1953216
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AT shaohualiu metabolismrelatedlongnoncodingrnaslncrnasaspotentialbiomarkersforpredictingriskofrecurrenceinbreastcancerpatients
AT jiechen metabolismrelatedlongnoncodingrnaslncrnasaspotentialbiomarkersforpredictingriskofrecurrenceinbreastcancerpatients
AT qinliu metabolismrelatedlongnoncodingrnaslncrnasaspotentialbiomarkersforpredictingriskofrecurrenceinbreastcancerpatients
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