Coordinated neuronal ensembles in primary auditory cortical columns

Coordinated neuronal ensembles in primary auditory cortical columns

The synchronous activity of groups of neurons is increasingly thought to be important in cortical information processing and transmission. However, most studies of processing in the primary auditory cortex (AI) have viewed neurons as independent filters; little is known about how coordinated AI neur...

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Main Authors: Jermyn Z See, Craig A Atencio, Vikaas S Sohal, Christoph E Schreiner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
auditory cortex
neuronal ensembles
spectrotemporal processing
Online Access:https://elifesciences.org/articles/35587
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spelling doaj-83c6d8d79d5e4efaa0193dcf1688a9962021-05-05T15:54:24ZengeLife Sciences Publications LtdeLife2050-084X2018-06-01710.7554/eLife.35587Coordinated neuronal ensembles in primary auditory cortical columnsJermyn Z See0https://orcid.org/0000-0002-8372-0753Craig A Atencio1Vikaas S Sohal2https://orcid.org/0000-0002-2238-4186Christoph E Schreiner3https://orcid.org/0000-0002-4571-4328UCSF Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States; Coleman Memorial Laboratory, University of California, San Francisco, San Francisco, United States; Department of Otolaryngology – Head and Neck Surgery, University of California, San Francisco, San Francisco, United States; Department of Psychiatry, University of California, San Francisco, United StatesUCSF Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States; Coleman Memorial Laboratory, University of California, San Francisco, San Francisco, United States; Department of Otolaryngology – Head and Neck Surgery, University of California, San Francisco, San Francisco, United StatesUCSF Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States; Department of Psychiatry, University of California, San Francisco, United StatesUCSF Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States; Coleman Memorial Laboratory, University of California, San Francisco, San Francisco, United States; Department of Otolaryngology – Head and Neck Surgery, University of California, San Francisco, San Francisco, United StatesThe synchronous activity of groups of neurons is increasingly thought to be important in cortical information processing and transmission. However, most studies of processing in the primary auditory cortex (AI) have viewed neurons as independent filters; little is known about how coordinated AI neuronal activity is expressed throughout cortical columns and how it might enhance the processing of auditory information. To address this, we recorded from populations of neurons in AI cortical columns of anesthetized rats and, using dimensionality reduction techniques, identified multiple coordinated neuronal ensembles (cNEs), which are groups of neurons with reliable synchronous activity. We show that cNEs reflect local network configurations with enhanced information encoding properties that cannot be accounted for by stimulus-driven synchronization alone. Furthermore, similar cNEs were identified in both spontaneous and evoked activity, indicating that columnar cNEs are stable functional constructs that may represent principal units of information processing in AI.https://elifesciences.org/articles/35587auditory cortexneuronal ensemblesspectrotemporal processing
collection DOAJ
language English
format Article
sources DOAJ
author Jermyn Z See
Craig A Atencio
Vikaas S Sohal
Christoph E Schreiner
spellingShingle Jermyn Z See
Craig A Atencio
Vikaas S Sohal
Christoph E Schreiner
Coordinated neuronal ensembles in primary auditory cortical columns
eLife
auditory cortex
neuronal ensembles
spectrotemporal processing
author_facet Jermyn Z See
Craig A Atencio
Vikaas S Sohal
Christoph E Schreiner
author_sort Jermyn Z See
title Coordinated neuronal ensembles in primary auditory cortical columns
title_short Coordinated neuronal ensembles in primary auditory cortical columns
title_full Coordinated neuronal ensembles in primary auditory cortical columns
title_fullStr Coordinated neuronal ensembles in primary auditory cortical columns
title_full_unstemmed Coordinated neuronal ensembles in primary auditory cortical columns
title_sort coordinated neuronal ensembles in primary auditory cortical columns
publisher eLife Sciences Publications Ltd
series eLife
issn 2050-084X
publishDate 2018-06-01
description The synchronous activity of groups of neurons is increasingly thought to be important in cortical information processing and transmission. However, most studies of processing in the primary auditory cortex (AI) have viewed neurons as independent filters; little is known about how coordinated AI neuronal activity is expressed throughout cortical columns and how it might enhance the processing of auditory information. To address this, we recorded from populations of neurons in AI cortical columns of anesthetized rats and, using dimensionality reduction techniques, identified multiple coordinated neuronal ensembles (cNEs), which are groups of neurons with reliable synchronous activity. We show that cNEs reflect local network configurations with enhanced information encoding properties that cannot be accounted for by stimulus-driven synchronization alone. Furthermore, similar cNEs were identified in both spontaneous and evoked activity, indicating that columnar cNEs are stable functional constructs that may represent principal units of information processing in AI.
topic auditory cortex
neuronal ensembles
spectrotemporal processing
url https://elifesciences.org/articles/35587
work_keys_str_mv AT jermynzsee coordinatedneuronalensemblesinprimaryauditorycorticalcolumns
AT craigaatencio coordinatedneuronalensemblesinprimaryauditorycorticalcolumns
AT vikaasssohal coordinatedneuronalensemblesinprimaryauditorycorticalcolumns
AT christopheschreiner coordinatedneuronalensemblesinprimaryauditorycorticalcolumns
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