Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines

• Main Authors: Xiaoming Ou, Jinwen Chen, Wenjing Xiao, Hanwen Liu, Zanwen Xia, Zhonghua Zhu, Zilong Tang
• Format: Article
• Language: English
• Published: MDPI AG 2012-07-01
• Series: Molecules
• Subjects: 2,3-disubstituted-1,3-benzoxazine; synthesis; chlorotrimethylsilane; fungicidal activity
• Online Access: http://www.mdpi.com/1420-3049/17/7/8174
• ISSN: 1420-3049

A series of new 2,3-disubstituted-3,4-dihydro-2<em>H</em>-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(<em>N</em>-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, MS and elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated, and some compounds exhibited good activity against <em>Rhizoctonia solani</em>.