The impact and distinction of ‘lipid healthy but obese’ and ‘lipid abnormal but not obese’ phenotypes on lumbar disc degeneration in Chinese

Abstract Background Lipid abnormality and obesity have been proposed to be associated with lumbar disc degeneration, but little is known about the effect of ‘lipid healthy but obese’ (LH-O) and ‘lipid abnormal but not obese’ (LA-NO) phenotypes on lumbar disc degeneration in Chinese. The study aims t...

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Main Authors: Sheng Shi, Zhi Zhou, Jun-Jun Liao, Yue-Hua Yang, Jun-Song Wu, Shuang Zheng, Shi-Sheng He
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Translational Medicine
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12967-020-02382-0
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spelling doaj-83dc2d5e8c2d46ec910b14aef18608c42020-11-25T03:18:09ZengBMCJournal of Translational Medicine1479-58762020-05-011811810.1186/s12967-020-02382-0The impact and distinction of ‘lipid healthy but obese’ and ‘lipid abnormal but not obese’ phenotypes on lumbar disc degeneration in ChineseSheng Shi0Zhi Zhou1Jun-Jun Liao2Yue-Hua Yang3Jun-Song Wu4Shuang Zheng5Shi-Sheng He6Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji UniversityDepartment of Orthopedics, Shanghai Tenth People’s Hospital, Tongji UniversityDepartment of Orthopedics, Fuzhou First People’s Hospital, Nanchang UniversityDepartment of Orthopedics, The Fifth Affiliated Hospital, Southern Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital, School of Medicine, Zhejiang UniversitySchool of Medicine, Shanghai UniversityDepartment of Orthopedics, Shanghai Tenth People’s Hospital, Tongji UniversityAbstract Background Lipid abnormality and obesity have been proposed to be associated with lumbar disc degeneration, but little is known about the effect of ‘lipid healthy but obese’ (LH-O) and ‘lipid abnormal but not obese’ (LA-NO) phenotypes on lumbar disc degeneration in Chinese. The study aims to determine the impact and distinction of LH-O and LA-NO phenotypes on lumbar disc degeneration in Chinese, and to identify the association of related factors with risk of lumbar disc degeneration. Methods A total of 678 individuals were included with lumbar magnetic resonance imaging, serum lipid levels and anthropometric measurements. Obesity was defined on the basis of body mass index or waist to hip ratio (WHR). Pfirrmann score and Weishaupt’s scale were utilized to assess the degree of disc degeneration and facet joint degeneration. Results The incidence of the LH-O and LA-NO phenotypes were 11.4% and 18.1%, respectively. LA-NO phenotype demonstrates a high incidence for disc degeneration (P < 0.05), while LH-O phenotype confers a severe disc degeneration grade (P < 0.05). No statistical difference in the percentage of severe facet joint degeneration grade in each group (P > 0.05). Elevated triglycerides and greater WHR may be the risk factors for lumbar disc degeneration in Chinese. Conclusion LH-O and LA-NO phenotypes are common with different status of disc degeneration in Chinese. Elevated triglycerides and abdominal obesity appear to play crucial roles in the development of lumbar disc degeneration.http://link.springer.com/article/10.1186/s12967-020-02382-0HyperlipidemiaLumbar disc degenerationFacet joint degenerationElevated triglycerideAbdominal obesity
collection DOAJ
language English
format Article
sources DOAJ
author Sheng Shi
Zhi Zhou
Jun-Jun Liao
Yue-Hua Yang
Jun-Song Wu
Shuang Zheng
Shi-Sheng He
spellingShingle Sheng Shi
Zhi Zhou
Jun-Jun Liao
Yue-Hua Yang
Jun-Song Wu
Shuang Zheng
Shi-Sheng He
The impact and distinction of ‘lipid healthy but obese’ and ‘lipid abnormal but not obese’ phenotypes on lumbar disc degeneration in Chinese
Journal of Translational Medicine
Hyperlipidemia
Lumbar disc degeneration
Facet joint degeneration
Elevated triglyceride
Abdominal obesity
author_facet Sheng Shi
Zhi Zhou
Jun-Jun Liao
Yue-Hua Yang
Jun-Song Wu
Shuang Zheng
Shi-Sheng He
author_sort Sheng Shi
title The impact and distinction of ‘lipid healthy but obese’ and ‘lipid abnormal but not obese’ phenotypes on lumbar disc degeneration in Chinese
title_short The impact and distinction of ‘lipid healthy but obese’ and ‘lipid abnormal but not obese’ phenotypes on lumbar disc degeneration in Chinese
title_full The impact and distinction of ‘lipid healthy but obese’ and ‘lipid abnormal but not obese’ phenotypes on lumbar disc degeneration in Chinese
title_fullStr The impact and distinction of ‘lipid healthy but obese’ and ‘lipid abnormal but not obese’ phenotypes on lumbar disc degeneration in Chinese
title_full_unstemmed The impact and distinction of ‘lipid healthy but obese’ and ‘lipid abnormal but not obese’ phenotypes on lumbar disc degeneration in Chinese
title_sort impact and distinction of ‘lipid healthy but obese’ and ‘lipid abnormal but not obese’ phenotypes on lumbar disc degeneration in chinese
publisher BMC
series Journal of Translational Medicine
issn 1479-5876
publishDate 2020-05-01
description Abstract Background Lipid abnormality and obesity have been proposed to be associated with lumbar disc degeneration, but little is known about the effect of ‘lipid healthy but obese’ (LH-O) and ‘lipid abnormal but not obese’ (LA-NO) phenotypes on lumbar disc degeneration in Chinese. The study aims to determine the impact and distinction of LH-O and LA-NO phenotypes on lumbar disc degeneration in Chinese, and to identify the association of related factors with risk of lumbar disc degeneration. Methods A total of 678 individuals were included with lumbar magnetic resonance imaging, serum lipid levels and anthropometric measurements. Obesity was defined on the basis of body mass index or waist to hip ratio (WHR). Pfirrmann score and Weishaupt’s scale were utilized to assess the degree of disc degeneration and facet joint degeneration. Results The incidence of the LH-O and LA-NO phenotypes were 11.4% and 18.1%, respectively. LA-NO phenotype demonstrates a high incidence for disc degeneration (P < 0.05), while LH-O phenotype confers a severe disc degeneration grade (P < 0.05). No statistical difference in the percentage of severe facet joint degeneration grade in each group (P > 0.05). Elevated triglycerides and greater WHR may be the risk factors for lumbar disc degeneration in Chinese. Conclusion LH-O and LA-NO phenotypes are common with different status of disc degeneration in Chinese. Elevated triglycerides and abdominal obesity appear to play crucial roles in the development of lumbar disc degeneration.
topic Hyperlipidemia
Lumbar disc degeneration
Facet joint degeneration
Elevated triglyceride
Abdominal obesity
url http://link.springer.com/article/10.1186/s12967-020-02382-0
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