The impact and distinction of ‘lipid healthy but obese’ and ‘lipid abnormal but not obese’ phenotypes on lumbar disc degeneration in Chinese

• Main Authors: Sheng Shi, Zhi Zhou, Jun-Jun Liao, Yue-Hua Yang, Jun-Song Wu, Shuang Zheng, Shi-Sheng He
• Format: Article
• Language: English
• Published: BMC 2020-05-01
• Series: Journal of Translational Medicine
• Subjects: Hyperlipidemia; Lumbar disc degeneration; Facet joint degeneration; Elevated triglyceride; Abdominal obesity
• Online Access: http://link.springer.com/article/10.1186/s12967-020-02382-0

Abstract Background Lipid abnormality and obesity have been proposed to be associated with lumbar disc degeneration, but little is known about the effect of ‘lipid healthy but obese’ (LH-O) and ‘lipid abnormal but not obese’ (LA-NO) phenotypes on lumbar disc degeneration in Chinese. The study aims to determine the impact and distinction of LH-O and LA-NO phenotypes on lumbar disc degeneration in Chinese, and to identify the association of related factors with risk of lumbar disc degeneration. Methods A total of 678 individuals were included with lumbar magnetic resonance imaging, serum lipid levels and anthropometric measurements. Obesity was defined on the basis of body mass index or waist to hip ratio (WHR). Pfirrmann score and Weishaupt’s scale were utilized to assess the degree of disc degeneration and facet joint degeneration. Results The incidence of the LH-O and LA-NO phenotypes were 11.4% and 18.1%, respectively. LA-NO phenotype demonstrates a high incidence for disc degeneration (P < 0.05), while LH-O phenotype confers a severe disc degeneration grade (P < 0.05). No statistical difference in the percentage of severe facet joint degeneration grade in each group (P > 0.05). Elevated triglycerides and greater WHR may be the risk factors for lumbar disc degeneration in Chinese. Conclusion LH-O and LA-NO phenotypes are common with different status of disc degeneration in Chinese. Elevated triglycerides and abdominal obesity appear to play crucial roles in the development of lumbar disc degeneration.