Distinct effects of IPSU and suvorexant on mouse sleep architecture
Dual orexin receptor (OXR) antagonists (DORAs) such as almorexant, SB-649868, suvorexant (MK-4305) and filorexant (MK-6096), have shown promise for the treatment of insomnias and sleep disorders. Whether antagonism of both OX1R and OX2R is necessary for sleep induction has been a matter of some deb...
Main Authors: | Daniel eHoyer, Thomas eDürst, Markus eFendt, Laura H Jacobson, Claudia eBetschart, Samuel eHintermann, Dirk eBehnke, Simona eCotesta, Grit eLaue, Silvio eOfner, Eric eLegangneux, Christine E Gee |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2013-12-01
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Series: | Frontiers in Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00235/full |
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