Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study
Alveolar Osteitis (AO) is a complication following the extraction of a tooth. AO manifests through localized pain in, and around, the extraction site, where the post-operative blood clot has been disintegrated. The aim of this single cohort study was to evaluate the outcome of a treatment of AO, usi...
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doaj-83df5a21cbbd4d33a41dde51aa76dc942020-11-25T02:14:01ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012019-10-011619369810.3390/ijerph16193698ijerph16193698Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical StudyJakub Suchánek0Romana Koberová Ivančaková1Radovan Mottl2Klára Zoe Browne3Kristýna Charlotte Pilneyová4Nela Pilbauerová5Jan Schmidt6Tereza Suchánková Kleplová7Department of Dentistry, Charles University – Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech RepublicDepartment of Dentistry, Charles University – Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech RepublicDepartment of Dentistry, Charles University – Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech RepublicDepartment of Histology and Embryology, Charles University – Faculty of Medicine in Hradec Králové, Šimkova 870, 500 03 Hradec Králové, Czech RepublicDepartment of Dentistry, Charles University – Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech RepublicDepartment of Dentistry, Charles University – Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech RepublicDepartment of Dentistry, Charles University – Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech RepublicDepartment of Dentistry, Charles University – Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech RepublicAlveolar Osteitis (AO) is a complication following the extraction of a tooth. AO manifests through localized pain in, and around, the extraction site, where the post-operative blood clot has been disintegrated. The aim of this single cohort study was to evaluate the outcome of a treatment of AO, using a pharmacological device composed of hyaluronic acid and octenidine dihydrochloride. The tested device is a sponge-like material, composed solely of a fully dissoluble medicaments (hyaluronic acid, calcium chloride, and octenidine dihydrochloride). It was designed to serve as a non-toxic, slow-dissolving antiseptic, that adheres to mucosa and obturates the wound. This study includes 58 subjects who were diagnosed with AO. The tested device was administered once daily until local pain subsided to < 20 mm of the Visual Analog Scale (VAS). The treatment was considered effective when the pain subsided to < 20 mm VAS in < 8 days of treatment; as per comparative studies. Our findings provide a statistically significant success rate of 96.0% (95.0% confidence interval of 75.75% to 97.8%) after pharmacological device administrations. No adverse medical effects were detected. Acquired data confirmed that lyophilized hyaluronic acid, combined with octenidine, is effective for the treatment of AO. The results are clinically important as AO is a common complication after third molar extractions.https://www.mdpi.com/1660-4601/16/19/3698alveolitis sicca dolorosaalveolar osteitisalveolalgiasodium hyaluronateoctenidine dihydrochlorideclinical studyfirst-in-man study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jakub Suchánek Romana Koberová Ivančaková Radovan Mottl Klára Zoe Browne Kristýna Charlotte Pilneyová Nela Pilbauerová Jan Schmidt Tereza Suchánková Kleplová |
spellingShingle |
Jakub Suchánek Romana Koberová Ivančaková Radovan Mottl Klára Zoe Browne Kristýna Charlotte Pilneyová Nela Pilbauerová Jan Schmidt Tereza Suchánková Kleplová Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study International Journal of Environmental Research and Public Health alveolitis sicca dolorosa alveolar osteitis alveolalgia sodium hyaluronate octenidine dihydrochloride clinical study first-in-man study |
author_facet |
Jakub Suchánek Romana Koberová Ivančaková Radovan Mottl Klára Zoe Browne Kristýna Charlotte Pilneyová Nela Pilbauerová Jan Schmidt Tereza Suchánková Kleplová |
author_sort |
Jakub Suchánek |
title |
Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study |
title_short |
Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study |
title_full |
Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study |
title_fullStr |
Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study |
title_full_unstemmed |
Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study |
title_sort |
hyaluronic acid-based medical device for treatment of alveolar osteitis—clinical study |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2019-10-01 |
description |
Alveolar Osteitis (AO) is a complication following the extraction of a tooth. AO manifests through localized pain in, and around, the extraction site, where the post-operative blood clot has been disintegrated. The aim of this single cohort study was to evaluate the outcome of a treatment of AO, using a pharmacological device composed of hyaluronic acid and octenidine dihydrochloride. The tested device is a sponge-like material, composed solely of a fully dissoluble medicaments (hyaluronic acid, calcium chloride, and octenidine dihydrochloride). It was designed to serve as a non-toxic, slow-dissolving antiseptic, that adheres to mucosa and obturates the wound. This study includes 58 subjects who were diagnosed with AO. The tested device was administered once daily until local pain subsided to < 20 mm of the Visual Analog Scale (VAS). The treatment was considered effective when the pain subsided to < 20 mm VAS in < 8 days of treatment; as per comparative studies. Our findings provide a statistically significant success rate of 96.0% (95.0% confidence interval of 75.75% to 97.8%) after pharmacological device administrations. No adverse medical effects were detected. Acquired data confirmed that lyophilized hyaluronic acid, combined with octenidine, is effective for the treatment of AO. The results are clinically important as AO is a common complication after third molar extractions. |
topic |
alveolitis sicca dolorosa alveolar osteitis alveolalgia sodium hyaluronate octenidine dihydrochloride clinical study first-in-man study |
url |
https://www.mdpi.com/1660-4601/16/19/3698 |
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