Amino acids as regulators of gene expression

<p>Abstract</p> <p>The role of amino acids as substrates for protein synthesis is well documented. However, a function for amino acids in modulating the signal transduction pathways that regulate mRNA translation has only recently been described. Interesting, some of the signaling...

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Main Authors:	Kimball Scot R, Jefferson Leonard S
Format:	Article
Language:	English
Published:	BMC 2004-08-01
Series:	Nutrition & Metabolism
Online Access:	http://www.nutritionandmetabolism.com/content/1/1/3

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spelling	doaj-83e4a0ff595e4ee4a965ec8d4fb239722020-11-25T01:26:56ZengBMCNutrition & Metabolism1743-70752004-08-0111310.1186/1743-7075-1-3Amino acids as regulators of gene expressionKimball Scot RJefferson Leonard S<p>Abstract</p> <p>The role of amino acids as substrates for protein synthesis is well documented. However, a function for amino acids in modulating the signal transduction pathways that regulate mRNA translation has only recently been described. Interesting, some of the signaling pathways regulated by amino acids overlap with those classically associated with the cellular response to hormones such as insulin and insulin-like growth factors. The focus of this review is on the signaling pathways regulated by amino acids, with a particular emphasis on the branched-chain amino acid leucine, and the steps in mRNA translation controlled by the signaling pathways.</p> http://www.nutritionandmetabolism.com/content/1/1/3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kimball Scot R Jefferson Leonard S
spellingShingle	Kimball Scot R Jefferson Leonard S Amino acids as regulators of gene expression Nutrition & Metabolism
author_facet	Kimball Scot R Jefferson Leonard S
author_sort	Kimball Scot R
title	Amino acids as regulators of gene expression
title_short	Amino acids as regulators of gene expression
title_full	Amino acids as regulators of gene expression
title_fullStr	Amino acids as regulators of gene expression
title_full_unstemmed	Amino acids as regulators of gene expression
title_sort	amino acids as regulators of gene expression
publisher	BMC
series	Nutrition & Metabolism
issn	1743-7075
publishDate	2004-08-01
description	<p>Abstract</p> <p>The role of amino acids as substrates for protein synthesis is well documented. However, a function for amino acids in modulating the signal transduction pathways that regulate mRNA translation has only recently been described. Interesting, some of the signaling pathways regulated by amino acids overlap with those classically associated with the cellular response to hormones such as insulin and insulin-like growth factors. The focus of this review is on the signaling pathways regulated by amino acids, with a particular emphasis on the branched-chain amino acid leucine, and the steps in mRNA translation controlled by the signaling pathways.</p>
url	http://www.nutritionandmetabolism.com/content/1/1/3
work_keys_str_mv	AT kimballscotr aminoacidsasregulatorsofgeneexpression AT jeffersonleonards aminoacidsasregulatorsofgeneexpression
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Amino acids as regulators of gene expression

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