Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions with genetic loci associated with cardiac phenotyp...

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Main Authors:	Mun-Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven W. Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg-Gunn, Mikhail Spivakov, Peter Fraser, Bernard D. Keavney
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04931-0

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spelling	doaj-83ebcba231fa46148d8363dbe91cb2fe2021-05-11T10:09:55ZengNature Publishing GroupNature Communications2041-17232018-06-019111010.1038/s41467-018-04931-0Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networksMun-Kit Choy0Biola M. Javierre1Simon G. Williams2Stephanie L. Baross3Yingjuan Liu4Steven W. Wingett5Artur Akbarov6Chris Wallace7Paula Freire-Pritchett8Peter J. Rugg-Gunn9Mikhail Spivakov10Peter Fraser11Bernard D. Keavney12Division of Cardiovascular Sciences, The University of ManchesterNuclear Dynamics Programme, The Babraham InstituteDivision of Cardiovascular Sciences, The University of ManchesterDivision of Cardiovascular Sciences, The University of ManchesterDivision of Cardiovascular Sciences, The University of ManchesterNuclear Dynamics Programme, The Babraham InstituteDivision of Cardiovascular Sciences, The University of ManchesterMRC Biostatistics Unit, University of CambridgeNuclear Dynamics Programme, The Babraham InstituteEpigenetics Programme, The Babraham InstituteNuclear Dynamics Programme, The Babraham InstituteNuclear Dynamics Programme, The Babraham InstituteDivision of Cardiovascular Sciences, The University of ManchesterHuman embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions with genetic loci associated with cardiac phenotypes.https://doi.org/10.1038/s41467-018-04931-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mun-Kit Choy Biola M. Javierre Simon G. Williams Stephanie L. Baross Yingjuan Liu Steven W. Wingett Artur Akbarov Chris Wallace Paula Freire-Pritchett Peter J. Rugg-Gunn Mikhail Spivakov Peter Fraser Bernard D. Keavney
spellingShingle	Mun-Kit Choy Biola M. Javierre Simon G. Williams Stephanie L. Baross Yingjuan Liu Steven W. Wingett Artur Akbarov Chris Wallace Paula Freire-Pritchett Peter J. Rugg-Gunn Mikhail Spivakov Peter Fraser Bernard D. Keavney Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks Nature Communications
author_facet	Mun-Kit Choy Biola M. Javierre Simon G. Williams Stephanie L. Baross Yingjuan Liu Steven W. Wingett Artur Akbarov Chris Wallace Paula Freire-Pritchett Peter J. Rugg-Gunn Mikhail Spivakov Peter Fraser Bernard D. Keavney
author_sort	Mun-Kit Choy
title	Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
title_short	Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
title_full	Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
title_fullStr	Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
title_full_unstemmed	Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
title_sort	promoter interactome of human embryonic stem cell-derived cardiomyocytes connects gwas regions to cardiac gene networks
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-06-01
description	Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions with genetic loci associated with cardiac phenotypes.
url	https://doi.org/10.1038/s41467-018-04931-0
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Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

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