Reproducible abscopal effect in a patient with lung cancer who underwent whole‐brain irradiation and atezolizumab administration

Reproducible abscopal effect in a patient with lung cancer who underwent whole‐brain irradiation and atezolizumab administration

Abstract Due to the emergence of immune checkpoint inhibitors, the abscopal effect has gained more attention. We report a case of extracranial abscopal effect after whole‐brain irradiation therapy due to brain metastasis. After the initial abscopal effect was confirmed, a second abscopal effect was...

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Main Authors: Takamasa Hotta, Takae Okuno, Mika Nakao, Yoshihiro Amano, Takeshi Isobe, Yukari Tsubata
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Thoracic Cancer
Subjects:
abscopal effect
atezolizumab
lung cancer
whole‐brain irradiation
Online Access:https://doi.org/10.1111/1759-7714.13875
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spelling doaj-83f3a058cd4449b99253b8b355b44d162021-03-12T06:46:34ZengWileyThoracic Cancer1759-77061759-77142021-03-0112698598810.1111/1759-7714.13875Reproducible abscopal effect in a patient with lung cancer who underwent whole‐brain irradiation and atezolizumab administrationTakamasa Hotta0Takae Okuno1Mika Nakao2Yoshihiro Amano3Takeshi Isobe4Yukari Tsubata5Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine Shimane University Izumo JapanDepartment of Internal Medicine, Division of Medical Oncology & Respiratory Medicine Shimane University Izumo JapanDepartment of Internal Medicine, Division of Medical Oncology & Respiratory Medicine Shimane University Izumo JapanDepartment of Internal Medicine, Division of Medical Oncology & Respiratory Medicine Shimane University Izumo JapanDepartment of Internal Medicine, Division of Medical Oncology & Respiratory Medicine Shimane University Izumo JapanDepartment of Internal Medicine, Division of Medical Oncology & Respiratory Medicine Shimane University Izumo JapanAbstract Due to the emergence of immune checkpoint inhibitors, the abscopal effect has gained more attention. We report a case of extracranial abscopal effect after whole‐brain irradiation therapy due to brain metastasis. After the initial abscopal effect was confirmed, a second abscopal effect was confirmed following radiation therapy for bone metastases. This case confirms the reproducibility of the abscopal effect. Moreover, the abscopal effect was not observed in metastatic lesions with low immunogenicity, even in the same patient.https://doi.org/10.1111/1759-7714.13875abscopal effectatezolizumablung cancerwhole‐brain irradiation
collection DOAJ
language English
format Article
sources DOAJ
author Takamasa Hotta
Takae Okuno
Mika Nakao
Yoshihiro Amano
Takeshi Isobe
Yukari Tsubata
spellingShingle Takamasa Hotta
Takae Okuno
Mika Nakao
Yoshihiro Amano
Takeshi Isobe
Yukari Tsubata
Reproducible abscopal effect in a patient with lung cancer who underwent whole‐brain irradiation and atezolizumab administration
Thoracic Cancer
abscopal effect
atezolizumab
lung cancer
whole‐brain irradiation
author_facet Takamasa Hotta
Takae Okuno
Mika Nakao
Yoshihiro Amano
Takeshi Isobe
Yukari Tsubata
author_sort Takamasa Hotta
title Reproducible abscopal effect in a patient with lung cancer who underwent whole‐brain irradiation and atezolizumab administration
title_short Reproducible abscopal effect in a patient with lung cancer who underwent whole‐brain irradiation and atezolizumab administration
title_full Reproducible abscopal effect in a patient with lung cancer who underwent whole‐brain irradiation and atezolizumab administration
title_fullStr Reproducible abscopal effect in a patient with lung cancer who underwent whole‐brain irradiation and atezolizumab administration
title_full_unstemmed Reproducible abscopal effect in a patient with lung cancer who underwent whole‐brain irradiation and atezolizumab administration
title_sort reproducible abscopal effect in a patient with lung cancer who underwent whole‐brain irradiation and atezolizumab administration
publisher Wiley
series Thoracic Cancer
issn 1759-7706
1759-7714
publishDate 2021-03-01
description Abstract Due to the emergence of immune checkpoint inhibitors, the abscopal effect has gained more attention. We report a case of extracranial abscopal effect after whole‐brain irradiation therapy due to brain metastasis. After the initial abscopal effect was confirmed, a second abscopal effect was confirmed following radiation therapy for bone metastases. This case confirms the reproducibility of the abscopal effect. Moreover, the abscopal effect was not observed in metastatic lesions with low immunogenicity, even in the same patient.
topic abscopal effect
atezolizumab
lung cancer
whole‐brain irradiation
url https://doi.org/10.1111/1759-7714.13875
work_keys_str_mv AT takamasahotta reproducibleabscopaleffectinapatientwithlungcancerwhounderwentwholebrainirradiationandatezolizumabadministration
AT takaeokuno reproducibleabscopaleffectinapatientwithlungcancerwhounderwentwholebrainirradiationandatezolizumabadministration
AT mikanakao reproducibleabscopaleffectinapatientwithlungcancerwhounderwentwholebrainirradiationandatezolizumabadministration
AT yoshihiroamano reproducibleabscopaleffectinapatientwithlungcancerwhounderwentwholebrainirradiationandatezolizumabadministration
AT takeshiisobe reproducibleabscopaleffectinapatientwithlungcancerwhounderwentwholebrainirradiationandatezolizumabadministration
AT yukaritsubata reproducibleabscopaleffectinapatientwithlungcancerwhounderwentwholebrainirradiationandatezolizumabadministration
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