SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic bou...
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| Format: | Article |
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Nature Publishing Group
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13224-z |
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doaj-8405b7ea05e8461086f8fdd56ee7dec82021-05-11T11:49:39ZengNature Publishing GroupNature Communications2041-17232019-11-0110111710.1038/s41467-019-13224-zSIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminalsMaria Andres-Alonso0Mohamed Raafet Ammar1Ioana Butnaru2Guilherme M. Gomes3Gustavo Acuña Sanhueza4Rajeev Raman5PingAn Yuanxiang6Maximilian Borgmeyer7Jeffrey Lopez-Rojas8Syed Ahsan Raza9Nicola Brice10Torben J. Hausrat11Tamar Macharadze12Silvia Diaz-Gonzalez13Mark Carlton14Antonio Virgilio Failla15Oliver Stork16Michaela Schweizer17Eckart D. Gundelfinger18Matthias Kneussel19Christina Spilker20Anna Karpova21Michael R. Kreutz22Leibniz Group ‘Dendritic Organelles and Synaptic Function’, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-EppendorfRG Neuroplasticity, Leibniz Institute for NeurobiologyRG Neuroplasticity, Leibniz Institute for NeurobiologyRG Neuroplasticity, Leibniz Institute for NeurobiologyRG Neuroplasticity, Leibniz Institute for NeurobiologyRG Neuroplasticity, Leibniz Institute for NeurobiologyRG Neuroplasticity, Leibniz Institute for NeurobiologyLeibniz Group ‘Dendritic Organelles and Synaptic Function’, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-EppendorfRG Neuroplasticity, Leibniz Institute for NeurobiologyDepartment of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke UniversityParadigm Therapeutics Ltd. Cambridge, UK CerevanceInstitute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-EppendorfRG Neuroplasticity, Leibniz Institute for NeurobiologyLeibniz Group ‘Dendritic Organelles and Synaptic Function’, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-EppendorfParadigm Therapeutics Ltd. Cambridge, UK CerevanceUKE Microscopy Imaging Facility, University Medical Center Hamburg-EppendorfDepartment of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke UniversityZMNH Core Facility Morphology and Electron Microscopy, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-EppendorfCenter for Behavioral Brain Sciences, Otto von Guericke UniversityInstitute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-EppendorfRG Neuroplasticity, Leibniz Institute for NeurobiologyRG Neuroplasticity, Leibniz Institute for NeurobiologyLeibniz Group ‘Dendritic Organelles and Synaptic Function’, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-EppendorfThere is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic boutons and that SIPA1L2, a member of the SIPA1L family of neuronal RapGAPs, associates via LC3b to TrkB-containing amphisomes to regulate its motility and signaling at the axon terminalshttps://doi.org/10.1038/s41467-019-13224-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Maria Andres-Alonso Mohamed Raafet Ammar Ioana Butnaru Guilherme M. Gomes Gustavo Acuña Sanhueza Rajeev Raman PingAn Yuanxiang Maximilian Borgmeyer Jeffrey Lopez-Rojas Syed Ahsan Raza Nicola Brice Torben J. Hausrat Tamar Macharadze Silvia Diaz-Gonzalez Mark Carlton Antonio Virgilio Failla Oliver Stork Michaela Schweizer Eckart D. Gundelfinger Matthias Kneussel Christina Spilker Anna Karpova Michael R. Kreutz |
| spellingShingle |
Maria Andres-Alonso Mohamed Raafet Ammar Ioana Butnaru Guilherme M. Gomes Gustavo Acuña Sanhueza Rajeev Raman PingAn Yuanxiang Maximilian Borgmeyer Jeffrey Lopez-Rojas Syed Ahsan Raza Nicola Brice Torben J. Hausrat Tamar Macharadze Silvia Diaz-Gonzalez Mark Carlton Antonio Virgilio Failla Oliver Stork Michaela Schweizer Eckart D. Gundelfinger Matthias Kneussel Christina Spilker Anna Karpova Michael R. Kreutz SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals Nature Communications |
| author_facet |
Maria Andres-Alonso Mohamed Raafet Ammar Ioana Butnaru Guilherme M. Gomes Gustavo Acuña Sanhueza Rajeev Raman PingAn Yuanxiang Maximilian Borgmeyer Jeffrey Lopez-Rojas Syed Ahsan Raza Nicola Brice Torben J. Hausrat Tamar Macharadze Silvia Diaz-Gonzalez Mark Carlton Antonio Virgilio Failla Oliver Stork Michaela Schweizer Eckart D. Gundelfinger Matthias Kneussel Christina Spilker Anna Karpova Michael R. Kreutz |
| author_sort |
Maria Andres-Alonso |
| title |
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals |
| title_short |
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals |
| title_full |
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals |
| title_fullStr |
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals |
| title_full_unstemmed |
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals |
| title_sort |
sipa1l2 controls trafficking and local signaling of trkb-containing amphisomes at presynaptic terminals |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-11-01 |
| description |
There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic boutons and that SIPA1L2, a member of the SIPA1L family of neuronal RapGAPs, associates via LC3b to TrkB-containing amphisomes to regulate its motility and signaling at the axon terminals |
| url |
https://doi.org/10.1038/s41467-019-13224-z |
| work_keys_str_mv |
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