Validation of the <i>SavvyCheck</i><sup>TM</sup><i> Vaginal Yeast Test</i> for Screening Pregnant Women for Vulvovaginal Candidosis: A Prospective, Cross-Sectional Study
Pregnant women have an increased risk of vulvovaginal candidosis. Recurrent candidosis is under debate as a contributor to preterm birth, and vertical transmission may cause diaper dermatitis and oral thrush in the newborn. Apart from cultural methods, the gold standard for diagnosing candidosis is...
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doaj-840b64a1241847ceb5385cee68a64af92021-03-21T00:03:48ZengMDPI AGJournal of Fungi2309-608X2021-03-01723323310.3390/jof7030233Validation of the <i>SavvyCheck</i><sup>TM</sup><i> Vaginal Yeast Test</i> for Screening Pregnant Women for Vulvovaginal Candidosis: A Prospective, Cross-Sectional StudyPhilipp Foessleitner0Herbert Kiss1Julia Deinsberger2Julia Ott3Lorenz Zierhut4Alex Farr5Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, A-1090 Vienna, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, A-1090 Vienna, AustriaSkin and Endothelium Research Division (SERD), Department of Dermatology, Medical University of Vienna, A-1090 Vienna, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, A-1090 Vienna, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, A-1090 Vienna, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, A-1090 Vienna, AustriaPregnant women have an increased risk of vulvovaginal candidosis. Recurrent candidosis is under debate as a contributor to preterm birth, and vertical transmission may cause diaper dermatitis and oral thrush in the newborn. Apart from cultural methods, the gold standard for diagnosing candidosis is Gram staining, which is time-consuming and requires laboratory facilities. The objective of this prospective study was to validate a point-of-care vaginal yeast detection assay <i>(SavvyCheck</i>Ô<i> Vaginal Yeast Test)</i> and to evaluate it in asymptomatic pregnant women. We enrolled 200 participants, 100 of whom had vulvovaginal candidosis according to Gram stain (study group) and 100 were healthy pregnant controls (control group). Of these, 22 participants (11%) had invalid test results. The point-of-care test of the remaining 85 and 93 study participants in the study and control groups, respectively, showed a sensitivity of 94.1%, specificity of 98.9%, positive predictive value of 90.3%, and negative predictive value of 99.4% when compared with Gram stain. In conclusion, we found a high correlation between the <i>SavvyCheck</i>Ô <i>Vaginal Yeast Test </i>and Gram-stained smears during pregnancy. This suggests a potential role of this point-of-care test as a screening tool for asymptomatic pregnant women in early gestation.https://www.mdpi.com/2309-608X/7/3/233antenatal care<i>Candida</i>point-of-care testpregnancyvulvovaginal candidosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Philipp Foessleitner Herbert Kiss Julia Deinsberger Julia Ott Lorenz Zierhut Alex Farr |
spellingShingle |
Philipp Foessleitner Herbert Kiss Julia Deinsberger Julia Ott Lorenz Zierhut Alex Farr Validation of the <i>SavvyCheck</i><sup>TM</sup><i> Vaginal Yeast Test</i> for Screening Pregnant Women for Vulvovaginal Candidosis: A Prospective, Cross-Sectional Study Journal of Fungi antenatal care <i>Candida</i> point-of-care test pregnancy vulvovaginal candidosis |
author_facet |
Philipp Foessleitner Herbert Kiss Julia Deinsberger Julia Ott Lorenz Zierhut Alex Farr |
author_sort |
Philipp Foessleitner |
title |
Validation of the <i>SavvyCheck</i><sup>TM</sup><i> Vaginal Yeast Test</i> for Screening Pregnant Women for Vulvovaginal Candidosis: A Prospective, Cross-Sectional Study |
title_short |
Validation of the <i>SavvyCheck</i><sup>TM</sup><i> Vaginal Yeast Test</i> for Screening Pregnant Women for Vulvovaginal Candidosis: A Prospective, Cross-Sectional Study |
title_full |
Validation of the <i>SavvyCheck</i><sup>TM</sup><i> Vaginal Yeast Test</i> for Screening Pregnant Women for Vulvovaginal Candidosis: A Prospective, Cross-Sectional Study |
title_fullStr |
Validation of the <i>SavvyCheck</i><sup>TM</sup><i> Vaginal Yeast Test</i> for Screening Pregnant Women for Vulvovaginal Candidosis: A Prospective, Cross-Sectional Study |
title_full_unstemmed |
Validation of the <i>SavvyCheck</i><sup>TM</sup><i> Vaginal Yeast Test</i> for Screening Pregnant Women for Vulvovaginal Candidosis: A Prospective, Cross-Sectional Study |
title_sort |
validation of the <i>savvycheck</i><sup>tm</sup><i> vaginal yeast test</i> for screening pregnant women for vulvovaginal candidosis: a prospective, cross-sectional study |
publisher |
MDPI AG |
series |
Journal of Fungi |
issn |
2309-608X |
publishDate |
2021-03-01 |
description |
Pregnant women have an increased risk of vulvovaginal candidosis. Recurrent candidosis is under debate as a contributor to preterm birth, and vertical transmission may cause diaper dermatitis and oral thrush in the newborn. Apart from cultural methods, the gold standard for diagnosing candidosis is Gram staining, which is time-consuming and requires laboratory facilities. The objective of this prospective study was to validate a point-of-care vaginal yeast detection assay <i>(SavvyCheck</i>Ô<i> Vaginal Yeast Test)</i> and to evaluate it in asymptomatic pregnant women. We enrolled 200 participants, 100 of whom had vulvovaginal candidosis according to Gram stain (study group) and 100 were healthy pregnant controls (control group). Of these, 22 participants (11%) had invalid test results. The point-of-care test of the remaining 85 and 93 study participants in the study and control groups, respectively, showed a sensitivity of 94.1%, specificity of 98.9%, positive predictive value of 90.3%, and negative predictive value of 99.4% when compared with Gram stain. In conclusion, we found a high correlation between the <i>SavvyCheck</i>Ô <i>Vaginal Yeast Test </i>and Gram-stained smears during pregnancy. This suggests a potential role of this point-of-care test as a screening tool for asymptomatic pregnant women in early gestation. |
topic |
antenatal care <i>Candida</i> point-of-care test pregnancy vulvovaginal candidosis |
url |
https://www.mdpi.com/2309-608X/7/3/233 |
work_keys_str_mv |
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