Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the Arena
Cancer metastasis occurs through a series of sequential steps, which involves dissemination of tumor cells from a primary site and colonization in distant tissues. To promote the invasion-metastasis cascade, carcinoma cells usually initiate a cell-biological program called epithelial-mesenchymal tra...
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Cell Physiol Biochem Press GmbH & Co KG
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doaj-840d505029b14ea6a1906a307a79cabb2020-11-24T21:28:57ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782017-12-014441665168010.1159/000485766485766Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the ArenaLei WangFan YangLin-Tao JiaAn-Gang YangCancer metastasis occurs through a series of sequential steps, which involves dissemination of tumor cells from a primary site and colonization in distant tissues. To promote the invasion-metastasis cascade, carcinoma cells usually initiate a cell-biological program called epithelial-mesenchymal transition (EMT), which is orchestrated by a set of master regulators, including TGF-β, Snail, ZEB and Twist families. The biological activities of these molecules are tightly regulated by a variety of cell-intrinsic pathways as well as extracellular cues. Recently, accumulating evidence indicates that long non-coding RNAs (lncRNAs) represent some of the most differentially expressed transcripts between primary and metastatic cancers. LncRNAs including MALAT1, HOTAIR, H19, LncRNA-ATB, and LincRNA-ROR have been reported to be involved in the process of EMT, mainly through cross-talking with master regulators of EMT. Thus, understanding the different and precise molecular mechanisms by which functional lncRNAs switch EMT on and off is important for opening up new avenues in lncRNA-directed diagnosis, prognosis, and therapeutic intervention against cancer.https://www.karger.com/Article/FullText/485766Epithelial-Mesenchymal TransitionTumor metastasisCrosstalkLong non-coding RNA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lei Wang Fan Yang Lin-Tao Jia An-Gang Yang |
spellingShingle |
Lei Wang Fan Yang Lin-Tao Jia An-Gang Yang Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the Arena Cellular Physiology and Biochemistry Epithelial-Mesenchymal Transition Tumor metastasis Crosstalk Long non-coding RNA |
author_facet |
Lei Wang Fan Yang Lin-Tao Jia An-Gang Yang |
author_sort |
Lei Wang |
title |
Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the Arena |
title_short |
Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the Arena |
title_full |
Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the Arena |
title_fullStr |
Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the Arena |
title_full_unstemmed |
Missing Links in Epithelial-Mesenchymal Transition: Long Non-Coding RNAs Enter the Arena |
title_sort |
missing links in epithelial-mesenchymal transition: long non-coding rnas enter the arena |
publisher |
Cell Physiol Biochem Press GmbH & Co KG |
series |
Cellular Physiology and Biochemistry |
issn |
1015-8987 1421-9778 |
publishDate |
2017-12-01 |
description |
Cancer metastasis occurs through a series of sequential steps, which involves dissemination of tumor cells from a primary site and colonization in distant tissues. To promote the invasion-metastasis cascade, carcinoma cells usually initiate a cell-biological program called epithelial-mesenchymal transition (EMT), which is orchestrated by a set of master regulators, including TGF-β, Snail, ZEB and Twist families. The biological activities of these molecules are tightly regulated by a variety of cell-intrinsic pathways as well as extracellular cues. Recently, accumulating evidence indicates that long non-coding RNAs (lncRNAs) represent some of the most differentially expressed transcripts between primary and metastatic cancers. LncRNAs including MALAT1, HOTAIR, H19, LncRNA-ATB, and LincRNA-ROR have been reported to be involved in the process of EMT, mainly through cross-talking with master regulators of EMT. Thus, understanding the different and precise molecular mechanisms by which functional lncRNAs switch EMT on and off is important for opening up new avenues in lncRNA-directed diagnosis, prognosis, and therapeutic intervention against cancer. |
topic |
Epithelial-Mesenchymal Transition Tumor metastasis Crosstalk Long non-coding RNA |
url |
https://www.karger.com/Article/FullText/485766 |
work_keys_str_mv |
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1725968291933978624 |