Molecular profiling of gastric cancer in a population with high HIV prevalence reveals a shift to MLH1 loss but not the EBV subtype

Molecular profiling of gastric cancer in a population with high HIV prevalence reveals a shift to MLH1 loss but not the EBV subtype

Abstract The human immunodeficiency virus (HIV) pandemic heavily affects sub‐Saharan Africa. It is associated with persistently active Epstein‐Barr virus (EBV) infection. To determine if this translates into increased frequency of EBV‐associated gastric cancer (EBVaGC), we evaluated molecular profil...

Full description

Bibliographic Details
Main Authors:	Violet Kayamba, Julia Butt, Tim Waterboer, Ellen Besa, Naheed Choudhry, Anglin Hamasuku, Peter Julius, Douglas C. Heimburger, Masharip Atadzhanov, Paul Kelly
Format:	Article
Language:	English
Published:	Wiley 2020-05-01
Series:	Cancer Medicine
Online Access:	https://doi.org/10.1002/cam4.3001

Similar Items

EBV-Infection in Cardiac and Non-Cardiac Gastric Adenocarcinomas is Associated with Promoter Methylation of p16, p14 and APC, but not hMLH1
by: Helene Geddert, et al.
Published: (2010-01-01)

Presence of blood in gastric juice: A sensitive marker for gastric cancer screening in a poor resource setting.
by: Violet Kayamba, et al.
Published: (2018-01-01)

High prevalence of gastric intestinal metaplasia detected by confocal laser endomicroscopy in Zambian adults.
by: Violet Kayamba, et al.
Published: (2017-01-01)

Gastric adenocarcinoma is not an HIV related malignancy
by: Kayamba Violet, et al.
Published: (2012-05-01)

Adenosine Induces EBV Lytic Reactivation through ADORA1 in EBV-Associated Gastric Carcinoma
by: Su Jin Choi, et al.
Published: (2019-03-01)

Task-shifting to optimize outpatient neurological care in Zambia
by: Ana C. Villegas, et al.
Published: (2021-07-01)

HIV infection, hypercoagulability and ischaemic stroke in adults at the University Teaching Hospital in Zambia: a case control study
by: Stanley Zimba, et al.
Published: (2017-05-01)

Functional analysis of MLH1
by: Hoffmann, Eva R.
Published: (2002)

Localization of MLH3 at the Centrosomes
by: Lennart M. Roesner, et al.
Published: (2014-08-01)

Expression of MGMT, hMLH1 and XRCC1 in Gastric Cancer Tissue and Their Clinical Significance
by: Xiao-feng LI, et al.
Published: (2015-03-01)

The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis
by: Lyla J. Stanland, et al.
Published: (2020-10-01)

Epstein-Barr Virus (EBV)-associated Gastric Carcinoma
by: Hironori Yoshiyama, et al.
Published: (2012-11-01)

Cancer Control in Low- and Middle-Income Countries: Is It Time to Consider Screening?
by: Shailja C. Shah, et al.
Published: (2019-03-01)

MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.
by: J Kim Holloway, et al.
Published: (2008-09-01)

Association Between hMLH1 Promoter Methylation and Risk of Gastric Cancer: A Meta-Analysis
by: Peng Ye, et al.
Published: (2018-04-01)

<it>MSH2 </it>and <it>MLH1 </it>testing
by: Kurzawski Grzegorz, et al.
Published: (2008-06-01)

EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives
by: Keran Sun, et al.
Published: (2020-12-01)

Assessing pathogenicity of <it>MLH1 </it>variants by co-expression of human <it>MLH1 </it>and <it>PMS2 </it>genes in yeast
by: Hudler Petra, et al.
Published: (2009-10-01)

Estimated 24-hour urinary sodium excretion as a risk factor for oxidative stress in Zambian adults: A cross-sectional study.
by: Violet Kayamba, et al.
Published: (2020-01-01)

Gastric EBV‐positive mucocutaneous ulcer: A rare pathological entity
by: Azza Gabsi, et al.
Published: (2020-07-01)

Clinicopathological Significance of EBV-Infected Gastric Carcinomas: A Meta-Analysis
by: Jung-Soo Pyo, et al.
Published: (2020-07-01)

MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link With Novel Immunotherapy
by: Maria Grazia Rodriquenz, et al.
Published: (2020-05-01)

The <it>MLH1 </it>2101C>A (Q701K) variant increases the risk of gastric cancer in Chinese males
by: Zhi Wenxian, et al.
Published: (2011-12-01)

Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer.
by: Kunitoshi Shigeyasu, et al.
Published: (2015-01-01)

MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway
by: Yue Li, et al.
Published: (2018-12-01)

Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
by: Ricardo Mouro Pinto, et al.
Published: (2013-10-01)

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans.
by: Carol M Manhart, et al.
Published: (2017-04-01)

A case of multifocal EBV associated gastric carcinoma with focal squamous differentiation
by: Kim Ji-Hoon, et al.
Published: (2019-01-01)

The genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma
by: Zhang-Hua Chen, et al.
Published: (2021-09-01)

The Role of MLH1 Constitutional Methylation in Lynch Syndrome
by: Diana Touceira Pinto
Published: (2019)

Assessment of Missense Alterations in MLH1 and their Pathogenic Significance
by: Perera, Needra Sheron
Published: (2010)

Assessment of Missense Alterations in MLH1 and their Pathogenic Significance
by: Perera, Needra Sheron
Published: (2010)

Interaction between the proteins c-MYC and MLH1
by: Robinson, Helen
Published: (2004)

The Role of MLH1 Response to Treatment in Oral Cancer
by: Lin-Han Lin, et al.
Published: (2015)

Coordinated and Independent Roles for MLH Subunits in DNA Repair
by: Gianno Pannafino, et al.
Published: (2021-04-01)

Evaluation of reactive Epstein-Barr virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS)
by: Nourollah Ramroodi, et al.
Published: (2013-04-01)

Nasopharyngeal carcinoma, an analysis of histological subtypes and their association with EBV, a study of 100 cases of Pakistani population
by: Beena Umar
Published: (2014-05-01)

Evaluation of reactive Epstein–Barr Virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS)
by: Nourollah Ramroodi, et al.
Published: (2013-03-01)

Evaluation of reactive Epstein-Barr virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS)
by: Nourollah Ramroodi, et al.

The roles of hMSH4-hMSH5 and hMLH1-hMLH3 in meiotic double strand break repair
by: Soukup, Randal J.
Published: (2016)