Preoperative elevation of serum C-reactive protein as an indicator of poor prognosis for early-stage esophageal squamous cell carcinoma
Preoperative elevation of serum C-reactive protein (CRP) is reportedly associated with poor prognosis in several types of cancer. This study investigated the role of serum CRP as a prognostic factor in early-stage esophageal squamous cell carcinoma (ESCC). The preoperative serum CRP levels were meas...
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doaj-8418a207923c4752b31389fa1403cf7c2020-11-25T01:40:07ZengWileyKaohsiung Journal of Medical Sciences1607-551X2013-12-01291266266610.1016/j.kjms.2013.01.016Preoperative elevation of serum C-reactive protein as an indicator of poor prognosis for early-stage esophageal squamous cell carcinomaZheng-Bo Song0Bao-Chai Lin1Bo Li2Chun-Xiao He3Bei-Bei Zhang4Lan Shao5Yi-Ping Zhang6Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, ChinaKey Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou, Zhejiang Province, ChinaDepartment of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, ChinaPreoperative elevation of serum C-reactive protein (CRP) is reportedly associated with poor prognosis in several types of cancer. This study investigated the role of serum CRP as a prognostic factor in early-stage esophageal squamous cell carcinoma (ESCC). The preoperative serum CRP levels were measured in 156 newly diagnosed pT1–2N0M0 patients using an enzyme-linked immunosorbent assay. Correlations between serum CRP levels and other clinical parameters were analyzed. Multivariate analyses were performed to find prognostic markers using Cox's proportional hazards model. CRP concentrations were within the normal range in 117 (75%) individuals, but were elevated in 39 (25%) patients. Serum CRP levels were significantly correlated with the tumor length (p = 0.032), depth (T classification, p = 0.0157), or histologic grade (p = 0.034). The overall 5-year survival rates were 76.3% and 50.2% in the low- and high-CRP groups, respectively (p = 0.005). By multivariate analyses, the elevated serum CRP level was found to be an independent prognostic factor for poor survival (hazard ratio = 2.131; p = 0.007), regardless of tumor classification or other prognostic factors. In conclusion, preoperative, high serum CRP is an independent determinant of poor prognosis in early-stage ESCC.http://www.sciencedirect.com/science/article/pii/S1607551X13001447C-reactive proteinEarly stageEsophageal squamous cell carcinomasPrognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zheng-Bo Song Bao-Chai Lin Bo Li Chun-Xiao He Bei-Bei Zhang Lan Shao Yi-Ping Zhang |
spellingShingle |
Zheng-Bo Song Bao-Chai Lin Bo Li Chun-Xiao He Bei-Bei Zhang Lan Shao Yi-Ping Zhang Preoperative elevation of serum C-reactive protein as an indicator of poor prognosis for early-stage esophageal squamous cell carcinoma Kaohsiung Journal of Medical Sciences C-reactive protein Early stage Esophageal squamous cell carcinomas Prognosis |
author_facet |
Zheng-Bo Song Bao-Chai Lin Bo Li Chun-Xiao He Bei-Bei Zhang Lan Shao Yi-Ping Zhang |
author_sort |
Zheng-Bo Song |
title |
Preoperative elevation of serum C-reactive protein as an indicator of poor prognosis for early-stage esophageal squamous cell carcinoma |
title_short |
Preoperative elevation of serum C-reactive protein as an indicator of poor prognosis for early-stage esophageal squamous cell carcinoma |
title_full |
Preoperative elevation of serum C-reactive protein as an indicator of poor prognosis for early-stage esophageal squamous cell carcinoma |
title_fullStr |
Preoperative elevation of serum C-reactive protein as an indicator of poor prognosis for early-stage esophageal squamous cell carcinoma |
title_full_unstemmed |
Preoperative elevation of serum C-reactive protein as an indicator of poor prognosis for early-stage esophageal squamous cell carcinoma |
title_sort |
preoperative elevation of serum c-reactive protein as an indicator of poor prognosis for early-stage esophageal squamous cell carcinoma |
publisher |
Wiley |
series |
Kaohsiung Journal of Medical Sciences |
issn |
1607-551X |
publishDate |
2013-12-01 |
description |
Preoperative elevation of serum C-reactive protein (CRP) is reportedly associated with poor prognosis in several types of cancer. This study investigated the role of serum CRP as a prognostic factor in early-stage esophageal squamous cell carcinoma (ESCC). The preoperative serum CRP levels were measured in 156 newly diagnosed pT1–2N0M0 patients using an enzyme-linked immunosorbent assay. Correlations between serum CRP levels and other clinical parameters were analyzed. Multivariate analyses were performed to find prognostic markers using Cox's proportional hazards model. CRP concentrations were within the normal range in 117 (75%) individuals, but were elevated in 39 (25%) patients. Serum CRP levels were significantly correlated with the tumor length (p = 0.032), depth (T classification, p = 0.0157), or histologic grade (p = 0.034). The overall 5-year survival rates were 76.3% and 50.2% in the low- and high-CRP groups, respectively (p = 0.005). By multivariate analyses, the elevated serum CRP level was found to be an independent prognostic factor for poor survival (hazard ratio = 2.131; p = 0.007), regardless of tumor classification or other prognostic factors. In conclusion, preoperative, high serum CRP is an independent determinant of poor prognosis in early-stage ESCC. |
topic |
C-reactive protein Early stage Esophageal squamous cell carcinomas Prognosis |
url |
http://www.sciencedirect.com/science/article/pii/S1607551X13001447 |
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