Long-Term Prognosis in Young Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention
Oren Yagel,* Naseem Shadafny,* Ran Eliaz, Gil Dagan, David Leibowitz, Ilgar Tahiroglu, David Planer, Offer Amir, Gabby Elbaz Greener,* Ronny Alcalai* Department of Cardiology, Hadassah Medical Center, Jerusalem, Israel; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel*These aut...
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doaj-8423b7dcdfce42eeae17080ac89f2f152021-04-20T18:55:24ZengDove Medical PressVascular Health and Risk Management1178-20482021-04-01Volume 1715315964046Long-Term Prognosis in Young Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary InterventionYagel OShadafny NEliaz RDagan GLeibowitz DTahiroglu IPlaner DAmir OElbaz Greener GAlcalai ROren Yagel,* Naseem Shadafny,* Ran Eliaz, Gil Dagan, David Leibowitz, Ilgar Tahiroglu, David Planer, Offer Amir, Gabby Elbaz Greener,* Ronny Alcalai* Department of Cardiology, Hadassah Medical Center, Jerusalem, Israel; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel*These authors contributed equally to this workCorrespondence: Gabby Elbaz GreenerHadassah Medical Center, Cardiology Division, Room Number 114, Jerusalem, IsraelTel +972(2)6776564Fax +972(2)6411028Email Gabby@hadassah.org.ilBackground: Acute coronary syndrome (ACS) at a young age is uncommon. Limited data regarding the long-term follow-up and prognosis in this population are available. Our objectives were to evaluate the long-term clinical outcomes of patients presenting with ACS at a young age and to assess factors that predict long-term prognosis.Methods: A retrospective analysis of consecutive young patients (male below 40 and female below 50 years old) that were admitted with ACS and underwent percutaneous coronary intervention (PCI) between the years 1997 and 2009. Demographics, clinical characteristics, and clinical outcomes including major cardiovascular (CV) events and mortality were analyzed. Multivariable cox proportional hazard model was performed to identify predictors of long-term prognosis.Results: One-hundred sixty-five patients were included with a mean follow-up of 9.1± 4.6 years. Most patients were men (88%), and mean age (years) was 36.8± 4.2. During follow-up, 15 (9.1%) died, 98 (59.4%) patients had at least one major CV event, 22 (13.3%) patients had more than two CV events, and the mean number of recurrent CV events was 1.4± 1.48 events per patient. In multivariate analysis, the strongest predictors of major CV events and/or mortality were coronary intervention without stent insertion (HR1.77; 95% CI 1.09– 2.9), LAD artery involvement (HR 1.59; 95% CI 1.04– 2.44) and hypertension (HR 1.6; 95% CI 1.0– 2.6).Conclusion: Patients with ACS in young age are at high risk for major CV and/or mortality in long-term follow-up with a high rate of recurrent CV events. Close follow-up and risk factor management for secondary prevention have a major role, particularly in this population.Keywords: acute coronary syndrome, ACS, NSTEMI, STEMI, young population, outcomeshttps://www.dovepress.com/long-term-prognosis-in-young-patients-with-acute-coronary-syndrome-tre-peer-reviewed-fulltext-article-VHRMacute coronary syndromeacsnstemistemiyoung populationoutcomes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yagel O Shadafny N Eliaz R Dagan G Leibowitz D Tahiroglu I Planer D Amir O Elbaz Greener G Alcalai R |
spellingShingle |
Yagel O Shadafny N Eliaz R Dagan G Leibowitz D Tahiroglu I Planer D Amir O Elbaz Greener G Alcalai R Long-Term Prognosis in Young Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention Vascular Health and Risk Management acute coronary syndrome acs nstemi stemi young population outcomes |
author_facet |
Yagel O Shadafny N Eliaz R Dagan G Leibowitz D Tahiroglu I Planer D Amir O Elbaz Greener G Alcalai R |
author_sort |
Yagel O |
title |
Long-Term Prognosis in Young Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention |
title_short |
Long-Term Prognosis in Young Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention |
title_full |
Long-Term Prognosis in Young Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention |
title_fullStr |
Long-Term Prognosis in Young Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention |
title_full_unstemmed |
Long-Term Prognosis in Young Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention |
title_sort |
long-term prognosis in young patients with acute coronary syndrome treated with percutaneous coronary intervention |
publisher |
Dove Medical Press |
series |
Vascular Health and Risk Management |
issn |
1178-2048 |
publishDate |
2021-04-01 |
description |
Oren Yagel,* Naseem Shadafny,* Ran Eliaz, Gil Dagan, David Leibowitz, Ilgar Tahiroglu, David Planer, Offer Amir, Gabby Elbaz Greener,* Ronny Alcalai* Department of Cardiology, Hadassah Medical Center, Jerusalem, Israel; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel*These authors contributed equally to this workCorrespondence: Gabby Elbaz GreenerHadassah Medical Center, Cardiology Division, Room Number 114, Jerusalem, IsraelTel +972(2)6776564Fax +972(2)6411028Email Gabby@hadassah.org.ilBackground: Acute coronary syndrome (ACS) at a young age is uncommon. Limited data regarding the long-term follow-up and prognosis in this population are available. Our objectives were to evaluate the long-term clinical outcomes of patients presenting with ACS at a young age and to assess factors that predict long-term prognosis.Methods: A retrospective analysis of consecutive young patients (male below 40 and female below 50 years old) that were admitted with ACS and underwent percutaneous coronary intervention (PCI) between the years 1997 and 2009. Demographics, clinical characteristics, and clinical outcomes including major cardiovascular (CV) events and mortality were analyzed. Multivariable cox proportional hazard model was performed to identify predictors of long-term prognosis.Results: One-hundred sixty-five patients were included with a mean follow-up of 9.1± 4.6 years. Most patients were men (88%), and mean age (years) was 36.8± 4.2. During follow-up, 15 (9.1%) died, 98 (59.4%) patients had at least one major CV event, 22 (13.3%) patients had more than two CV events, and the mean number of recurrent CV events was 1.4± 1.48 events per patient. In multivariate analysis, the strongest predictors of major CV events and/or mortality were coronary intervention without stent insertion (HR1.77; 95% CI 1.09– 2.9), LAD artery involvement (HR 1.59; 95% CI 1.04– 2.44) and hypertension (HR 1.6; 95% CI 1.0– 2.6).Conclusion: Patients with ACS in young age are at high risk for major CV and/or mortality in long-term follow-up with a high rate of recurrent CV events. Close follow-up and risk factor management for secondary prevention have a major role, particularly in this population.Keywords: acute coronary syndrome, ACS, NSTEMI, STEMI, young population, outcomes |
topic |
acute coronary syndrome acs nstemi stemi young population outcomes |
url |
https://www.dovepress.com/long-term-prognosis-in-young-patients-with-acute-coronary-syndrome-tre-peer-reviewed-fulltext-article-VHRM |
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