Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats.
By catabolizing glucose and lipids, mitochondria produce ATPs to meet energy demands. When the number and activity of mitochondria are not sufficient, the human body becomes easily fatigued due to the lack of ATP, thus the control of the quantity and function of mitochondria is important to optimize...
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2012-01-01
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doaj-84262baf81c6460aa384170bc177193b2020-11-24T21:18:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0177e4007310.1371/journal.pone.0040073Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats.Hyun Woo JeongSi Young ChoShinae KimEui Seok ShinJae Man KimMin Jeong SongPil Joon ParkJong Hee SohnHyon ParkDae-Bang SeoWan Gi KimSang-Jun LeeBy catabolizing glucose and lipids, mitochondria produce ATPs to meet energy demands. When the number and activity of mitochondria are not sufficient, the human body becomes easily fatigued due to the lack of ATP, thus the control of the quantity and function of mitochondria is important to optimize energy balance. By increasing mitochondrial capacity? it may be possible to enhance energy metabolism and improve exercise endurance. Here, through the screening of various functional food ingredients, we found that chitooligosaccharide (COS) is an effective inducer of mitochondrial biogenesis. In rodents, COS increased the mitochondrial content in skeletal muscle and enhanced exercise endurance. In cultured myocytes, the expression of major regulators of mitochondrial biogenesis and key components of mitochondrial electron transfer chain was increased upon COS treatment. COS-mediated induction of mitochondrial biogenesis was achieved in part by the activation of silent information regulator two ortholog 1 (Sirt1) and AMP-activated protein kinase (AMPK). Taken together, our data suggest that COS could act as an exercise mimetic by inducing mitochondrial biogenesis and enhancing exercise endurance through the activation of Sirt1 and AMPK.http://europepmc.org/articles/PMC3394803?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyun Woo Jeong Si Young Cho Shinae Kim Eui Seok Shin Jae Man Kim Min Jeong Song Pil Joon Park Jong Hee Sohn Hyon Park Dae-Bang Seo Wan Gi Kim Sang-Jun Lee |
spellingShingle |
Hyun Woo Jeong Si Young Cho Shinae Kim Eui Seok Shin Jae Man Kim Min Jeong Song Pil Joon Park Jong Hee Sohn Hyon Park Dae-Bang Seo Wan Gi Kim Sang-Jun Lee Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats. PLoS ONE |
author_facet |
Hyun Woo Jeong Si Young Cho Shinae Kim Eui Seok Shin Jae Man Kim Min Jeong Song Pil Joon Park Jong Hee Sohn Hyon Park Dae-Bang Seo Wan Gi Kim Sang-Jun Lee |
author_sort |
Hyun Woo Jeong |
title |
Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats. |
title_short |
Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats. |
title_full |
Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats. |
title_fullStr |
Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats. |
title_full_unstemmed |
Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats. |
title_sort |
chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of sirt1 and ampk in rats. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
By catabolizing glucose and lipids, mitochondria produce ATPs to meet energy demands. When the number and activity of mitochondria are not sufficient, the human body becomes easily fatigued due to the lack of ATP, thus the control of the quantity and function of mitochondria is important to optimize energy balance. By increasing mitochondrial capacity? it may be possible to enhance energy metabolism and improve exercise endurance. Here, through the screening of various functional food ingredients, we found that chitooligosaccharide (COS) is an effective inducer of mitochondrial biogenesis. In rodents, COS increased the mitochondrial content in skeletal muscle and enhanced exercise endurance. In cultured myocytes, the expression of major regulators of mitochondrial biogenesis and key components of mitochondrial electron transfer chain was increased upon COS treatment. COS-mediated induction of mitochondrial biogenesis was achieved in part by the activation of silent information regulator two ortholog 1 (Sirt1) and AMP-activated protein kinase (AMPK). Taken together, our data suggest that COS could act as an exercise mimetic by inducing mitochondrial biogenesis and enhancing exercise endurance through the activation of Sirt1 and AMPK. |
url |
http://europepmc.org/articles/PMC3394803?pdf=render |
work_keys_str_mv |
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