Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features
Introduction. Breast cancer with mammographic casting type calcifications, high grade DCIS with an abnormal number of ducts, periductal desmoplastic reaction, lymphocyte infiltration, and tenascin-C (TN-C) overexpression has been proposed to represent a more aggressive form of breast cancer and has...
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doaj-842ec433f9be4dbba9dc572939ba75992020-11-24T23:22:40ZengHindawi LimitedInternational Journal of Breast Cancer2090-31702090-31892014-01-01201410.1155/2014/581706581706Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour FeaturesWenjing Zhou0Thomas Sollie1Tibor Tot2Sarah E. Pinder3Rose-Marie Amini4Carl Blomqvist5Marie-Louise Fjällskog6Gunilla Christensson7Shahin Abdsaleh8Fredrik Wärnberg9Department of Surgical Sciences, Uppsala University, 751 85 Uppsala, SwedenDepartment of Pathology, Örebro University, 701 85 Örebro, SwedenDepartment of Pathology, Falun Central Hospital, 791 82 Falun, SwedenDepartment of Research Oncology, King’s College London, London SE1 9RT, UKDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, SwedenDepartment of Oncology, Helsinki University Central Hospital, 00029 Helsinki, FinlandDepartment of Radiology, Oncology and Radiation Science, Uppsala University, 751 85 Uppsala, SwedenDepartment of Surgery, Falun Central Hospital, 791 82 Falun, SwedenDepartment of Radiology, Oncology and Radiation Science, Uppsala University, 751 85 Uppsala, SwedenDepartment of Surgical Sciences, Uppsala University, 751 85 Uppsala, SwedenIntroduction. Breast cancer with mammographic casting type calcifications, high grade DCIS with an abnormal number of ducts, periductal desmoplastic reaction, lymphocyte infiltration, and tenascin-C (TN-C) overexpression has been proposed to represent a more aggressive form of breast cancer and has been denominated as breast cancer with neoductgenesis. We developed histopathological criteria for neoductgenesis in order to study reproducibility and correlation with other tumour markers. Methods. 74 cases of grades 2 and 3 DCIS, with or without an invasive component, were selected. A combined score of the degree(s) of concentration of ducts, lymphocyte infiltration, and periductal fibrosis was used to classify cases as showing neoductgenesis, or not. Diagnostic reproducibility, correlation with tumour markers, and mammographic features were studied. Results. Twenty-three of 74 cases were diagnosed with neoductgenesis. The kappa value between pathologists showed moderate reproducibility (0.50) (95% CI; 0.41–0.60). Neoductgenesis correlated significantly with malignant type microcalcifications and TN-C expression (P=0.008 and 0.04) and with ER, PR, and HER2 status (P<0.00001 for all three markers). Conclusions. We developed histological criteria for breast cancer with neoductgenesis. Neoductgenesis, by our applied histopathological definition was related to more aggressive tumour biology and malignant mammographic calcifications.http://dx.doi.org/10.1155/2014/581706 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenjing Zhou Thomas Sollie Tibor Tot Sarah E. Pinder Rose-Marie Amini Carl Blomqvist Marie-Louise Fjällskog Gunilla Christensson Shahin Abdsaleh Fredrik Wärnberg |
spellingShingle |
Wenjing Zhou Thomas Sollie Tibor Tot Sarah E. Pinder Rose-Marie Amini Carl Blomqvist Marie-Louise Fjällskog Gunilla Christensson Shahin Abdsaleh Fredrik Wärnberg Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features International Journal of Breast Cancer |
author_facet |
Wenjing Zhou Thomas Sollie Tibor Tot Sarah E. Pinder Rose-Marie Amini Carl Blomqvist Marie-Louise Fjällskog Gunilla Christensson Shahin Abdsaleh Fredrik Wärnberg |
author_sort |
Wenjing Zhou |
title |
Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features |
title_short |
Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features |
title_full |
Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features |
title_fullStr |
Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features |
title_full_unstemmed |
Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features |
title_sort |
breast cancer with neoductgenesis: histopathological criteria and its correlation with mammographic and tumour features |
publisher |
Hindawi Limited |
series |
International Journal of Breast Cancer |
issn |
2090-3170 2090-3189 |
publishDate |
2014-01-01 |
description |
Introduction. Breast cancer with mammographic casting type calcifications, high grade DCIS with an abnormal number of ducts, periductal desmoplastic reaction, lymphocyte infiltration, and tenascin-C (TN-C) overexpression has been proposed to represent a more aggressive form of breast cancer and has been denominated as breast cancer with neoductgenesis. We developed histopathological criteria for neoductgenesis in order to study reproducibility and correlation with other tumour markers. Methods. 74 cases of grades 2 and 3 DCIS, with or without an invasive component, were selected. A combined score of the degree(s) of concentration of ducts, lymphocyte infiltration, and periductal fibrosis was used to classify cases as showing neoductgenesis, or not. Diagnostic reproducibility, correlation with tumour markers, and mammographic features were studied. Results. Twenty-three of 74 cases were diagnosed with neoductgenesis. The kappa value between pathologists showed moderate reproducibility (0.50) (95% CI; 0.41–0.60). Neoductgenesis correlated significantly with malignant type microcalcifications and TN-C expression (P=0.008 and 0.04) and with ER, PR, and HER2 status (P<0.00001 for all three markers). Conclusions. We developed histological criteria for breast cancer with neoductgenesis. Neoductgenesis, by our applied histopathological definition was related to more aggressive tumour biology and malignant mammographic calcifications. |
url |
http://dx.doi.org/10.1155/2014/581706 |
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