The effects of chikungunya virus infection on people living with HIV during the 2014 Martinique outbreak.
Our objective was to describe the clinical presentation of chikungunya virus (CHIKV) infection in patients living with HIV (PLHIV) during the 2014 Martinique outbreak. During the outbreak and the 6 following months, all PLHIV coming in our unit for a medical evaluation answered questions about poten...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0234267 |
id |
doaj-8439c9d48c7348e69b3e56fd843c6551 |
---|---|
record_format |
Article |
spelling |
doaj-8439c9d48c7348e69b3e56fd843c65512021-03-03T21:51:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01156e023426710.1371/journal.pone.0234267The effects of chikungunya virus infection on people living with HIV during the 2014 Martinique outbreak.Mathilde PircherEdwin PitonoSandrine Pierre-FrançoisSabine MolcardLauren Brunier-AgotLaurence FagourFatiha NajioullahRaymond CesaireSylvie AbelLise CuzinAndré CabiéOur objective was to describe the clinical presentation of chikungunya virus (CHIKV) infection in patients living with HIV (PLHIV) during the 2014 Martinique outbreak. During the outbreak and the 6 following months, all PLHIV coming in our unit for a medical evaluation answered questions about potential CHIKV related symptoms, and had blood tests to assess the diagnosis. For patients coming in at the acute phase of infection, we are able to provide and analyze CD4+, CD8+ T-cells and HIV viral load evolution before, during and after CHIK infection. Among the 1 003 PLHIV in care in the center at the time of the outbreak, 188 (94 men and 94 women) had confirmed (following the WHO definition) CHIKV infection. Clinical presentation was common in 63% of the cases, severe and atypical forms were scarce. During the acute phase, CD4+ and CD8+ T-cells (evaluated in 30 PLHIV, 15 men and 15 women) absolute numbers dropped significantly, but returned to pre-CHIKV values after the acute phase. Reassuringly, CD4 and CD8 T cells proportions did not decrease during the acute phase. CHIKV infection had no significant impact on this anti-retroviral treated population.https://doi.org/10.1371/journal.pone.0234267 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mathilde Pircher Edwin Pitono Sandrine Pierre-François Sabine Molcard Lauren Brunier-Agot Laurence Fagour Fatiha Najioullah Raymond Cesaire Sylvie Abel Lise Cuzin André Cabié |
spellingShingle |
Mathilde Pircher Edwin Pitono Sandrine Pierre-François Sabine Molcard Lauren Brunier-Agot Laurence Fagour Fatiha Najioullah Raymond Cesaire Sylvie Abel Lise Cuzin André Cabié The effects of chikungunya virus infection on people living with HIV during the 2014 Martinique outbreak. PLoS ONE |
author_facet |
Mathilde Pircher Edwin Pitono Sandrine Pierre-François Sabine Molcard Lauren Brunier-Agot Laurence Fagour Fatiha Najioullah Raymond Cesaire Sylvie Abel Lise Cuzin André Cabié |
author_sort |
Mathilde Pircher |
title |
The effects of chikungunya virus infection on people living with HIV during the 2014 Martinique outbreak. |
title_short |
The effects of chikungunya virus infection on people living with HIV during the 2014 Martinique outbreak. |
title_full |
The effects of chikungunya virus infection on people living with HIV during the 2014 Martinique outbreak. |
title_fullStr |
The effects of chikungunya virus infection on people living with HIV during the 2014 Martinique outbreak. |
title_full_unstemmed |
The effects of chikungunya virus infection on people living with HIV during the 2014 Martinique outbreak. |
title_sort |
effects of chikungunya virus infection on people living with hiv during the 2014 martinique outbreak. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2020-01-01 |
description |
Our objective was to describe the clinical presentation of chikungunya virus (CHIKV) infection in patients living with HIV (PLHIV) during the 2014 Martinique outbreak. During the outbreak and the 6 following months, all PLHIV coming in our unit for a medical evaluation answered questions about potential CHIKV related symptoms, and had blood tests to assess the diagnosis. For patients coming in at the acute phase of infection, we are able to provide and analyze CD4+, CD8+ T-cells and HIV viral load evolution before, during and after CHIK infection. Among the 1 003 PLHIV in care in the center at the time of the outbreak, 188 (94 men and 94 women) had confirmed (following the WHO definition) CHIKV infection. Clinical presentation was common in 63% of the cases, severe and atypical forms were scarce. During the acute phase, CD4+ and CD8+ T-cells (evaluated in 30 PLHIV, 15 men and 15 women) absolute numbers dropped significantly, but returned to pre-CHIKV values after the acute phase. Reassuringly, CD4 and CD8 T cells proportions did not decrease during the acute phase. CHIKV infection had no significant impact on this anti-retroviral treated population. |
url |
https://doi.org/10.1371/journal.pone.0234267 |
work_keys_str_mv |
AT mathildepircher theeffectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT edwinpitono theeffectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT sandrinepierrefrancois theeffectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT sabinemolcard theeffectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT laurenbrunieragot theeffectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT laurencefagour theeffectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT fatihanajioullah theeffectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT raymondcesaire theeffectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT sylvieabel theeffectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT lisecuzin theeffectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT andrecabie theeffectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT mathildepircher effectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT edwinpitono effectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT sandrinepierrefrancois effectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT sabinemolcard effectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT laurenbrunieragot effectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT laurencefagour effectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT fatihanajioullah effectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT raymondcesaire effectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT sylvieabel effectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT lisecuzin effectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak AT andrecabie effectsofchikungunyavirusinfectiononpeoplelivingwithhivduringthe2014martiniqueoutbreak |
_version_ |
1714814804576698368 |