Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity

A series of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives were synthesized by the reaction of different aldehydes with 2-chloropyrimidin-4-amine and in vitro antimicrobial activity was evaluated. The synthesized compounds were characterize...

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Main Authors:	C. Mallikarjunaswamy, D.G. Bhadregowda, L. Mallesha
Format:	Article
Language:	English
Published:	Elsevier 2016-09-01
Series:	Journal of Saudi Chemical Society
Subjects:	Pyrimidines Schiff bases Antimicrobial activity Antifungal activity
Online Access:	http://www.sciencedirect.com/science/article/pii/S1319610313000495

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spelling	doaj-843ab27d56d84db9b406450c17c417b32020-11-24T20:57:01ZengElsevierJournal of Saudi Chemical Society1319-61032016-09-0120S1S606S61410.1016/j.jscs.2013.04.005Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activityC. Mallikarjunaswamy0D.G. Bhadregowda1L. Mallesha2Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore 570005, IndiaDepartment of Chemistry, Yuvaraja’s College, University of Mysore, Mysore 570005, IndiaPG Department of Chemistry, JSS College of Arts, Commerce and Science, Ooty Road, Mysore 570025, IndiaA series of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives were synthesized by the reaction of different aldehydes with 2-chloropyrimidin-4-amine and in vitro antimicrobial activity was evaluated. The synthesized compounds were characterized by elemental analyses, FT-IR, 1H NMR and LC–MS spectral studies. Antimicrobial data revealed that among all the compounds screened, compounds 7l and 7m were found to have promising antimicrobial activity against all the selected pathogenic bacteria and fungi.http://www.sciencedirect.com/science/article/pii/S1319610313000495PyrimidinesSchiff basesAntimicrobial activityAntifungal activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	C. Mallikarjunaswamy D.G. Bhadregowda L. Mallesha
spellingShingle	C. Mallikarjunaswamy D.G. Bhadregowda L. Mallesha Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity Journal of Saudi Chemical Society Pyrimidines Schiff bases Antimicrobial activity Antifungal activity
author_facet	C. Mallikarjunaswamy D.G. Bhadregowda L. Mallesha
author_sort	C. Mallikarjunaswamy
title	Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity
title_short	Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity
title_full	Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity
title_fullStr	Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity
title_full_unstemmed	Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity
title_sort	synthesis of novel (e)-n′-(2-chloropyrimidin-4-yl)-n-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity
publisher	Elsevier
series	Journal of Saudi Chemical Society
issn	1319-6103
publishDate	2016-09-01
description	A series of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives were synthesized by the reaction of different aldehydes with 2-chloropyrimidin-4-amine and in vitro antimicrobial activity was evaluated. The synthesized compounds were characterized by elemental analyses, FT-IR, 1H NMR and LC–MS spectral studies. Antimicrobial data revealed that among all the compounds screened, compounds 7l and 7m were found to have promising antimicrobial activity against all the selected pathogenic bacteria and fungi.
topic	Pyrimidines Schiff bases Antimicrobial activity Antifungal activity
url	http://www.sciencedirect.com/science/article/pii/S1319610313000495
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Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity

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