Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity
A series of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives were synthesized by the reaction of different aldehydes with 2-chloropyrimidin-4-amine and in vitro antimicrobial activity was evaluated. The synthesized compounds were characterize...
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doaj-843ab27d56d84db9b406450c17c417b32020-11-24T20:57:01ZengElsevierJournal of Saudi Chemical Society1319-61032016-09-0120S1S606S61410.1016/j.jscs.2013.04.005Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activityC. Mallikarjunaswamy0D.G. Bhadregowda1L. Mallesha2Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore 570005, IndiaDepartment of Chemistry, Yuvaraja’s College, University of Mysore, Mysore 570005, IndiaPG Department of Chemistry, JSS College of Arts, Commerce and Science, Ooty Road, Mysore 570025, IndiaA series of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives were synthesized by the reaction of different aldehydes with 2-chloropyrimidin-4-amine and in vitro antimicrobial activity was evaluated. The synthesized compounds were characterized by elemental analyses, FT-IR, 1H NMR and LC–MS spectral studies. Antimicrobial data revealed that among all the compounds screened, compounds 7l and 7m were found to have promising antimicrobial activity against all the selected pathogenic bacteria and fungi.http://www.sciencedirect.com/science/article/pii/S1319610313000495PyrimidinesSchiff basesAntimicrobial activityAntifungal activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
C. Mallikarjunaswamy D.G. Bhadregowda L. Mallesha |
spellingShingle |
C. Mallikarjunaswamy D.G. Bhadregowda L. Mallesha Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity Journal of Saudi Chemical Society Pyrimidines Schiff bases Antimicrobial activity Antifungal activity |
author_facet |
C. Mallikarjunaswamy D.G. Bhadregowda L. Mallesha |
author_sort |
C. Mallikarjunaswamy |
title |
Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity |
title_short |
Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity |
title_full |
Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity |
title_fullStr |
Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity |
title_full_unstemmed |
Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity |
title_sort |
synthesis of novel (e)-n′-(2-chloropyrimidin-4-yl)-n-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity |
publisher |
Elsevier |
series |
Journal of Saudi Chemical Society |
issn |
1319-6103 |
publishDate |
2016-09-01 |
description |
A series of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives were synthesized by the reaction of different aldehydes with 2-chloropyrimidin-4-amine and in vitro antimicrobial activity was evaluated. The synthesized compounds were characterized by elemental analyses, FT-IR, 1H NMR and LC–MS spectral studies. Antimicrobial data revealed that among all the compounds screened, compounds 7l and 7m were found to have promising antimicrobial activity against all the selected pathogenic bacteria and fungi. |
topic |
Pyrimidines Schiff bases Antimicrobial activity Antifungal activity |
url |
http://www.sciencedirect.com/science/article/pii/S1319610313000495 |
work_keys_str_mv |
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