A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors
BAFF is an important cytokine for B cell survival, and is a therapeutic target for autoimmune disorders. Here the authors show that a 'flap' region of BAFF converts BAFFR binding events into survival signals and, with structural data, that this ‘flap’ differentially modulates binding of dr...
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Nature Publishing Group
2018-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03323-8 |
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doaj-843bbc0b96a640bc806daedcfd909b7b2021-05-11T09:46:26ZengNature Publishing GroupNature Communications2041-17232018-03-019111510.1038/s41467-018-03323-8A loop region of BAFF controls B cell survival and regulates recognition by different inhibitorsMichele Vigolo0Melissa G. Chambers1Laure Willen2Dehlia Chevalley3Klaus Maskos4Alfred Lammens5Aubry Tardivel6Dolon Das7Christine Kowalczyk-Quintas8Sonia Schuepbach-Mallepell9Cristian R. Smulski10Mahya Eslami11Antonius Rolink12Edith Hummler13Eileen Samy14Yves Fomekong Nanfack15Fabienne Mackay16Maofu Liao17Henry Hess18Xuliang Jiang19Pascal Schneider20Department of Biochemistry, University of LausanneDepartment of Cell Biology, Harvard Medical SchoolDepartment of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneProteros Biostructures GmbHProteros Biostructures GmbHDepartment of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneDepartment of Biomedicine, University of BaselDepartment of Pharmacology and Toxicology, University of LausanneEMD Serono Research & Development InstituteEMD Serono Research & Development InstituteDepartment of Immunology, Monash UniversityDepartment of Cell Biology, Harvard Medical SchoolMerck KGaAEMD Serono Research & Development InstituteDepartment of Biochemistry, University of LausanneBAFF is an important cytokine for B cell survival, and is a therapeutic target for autoimmune disorders. Here the authors show that a 'flap' region of BAFF converts BAFFR binding events into survival signals and, with structural data, that this ‘flap’ differentially modulates binding of drugs such as belimumab or atacicept.https://doi.org/10.1038/s41467-018-03323-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Michele Vigolo Melissa G. Chambers Laure Willen Dehlia Chevalley Klaus Maskos Alfred Lammens Aubry Tardivel Dolon Das Christine Kowalczyk-Quintas Sonia Schuepbach-Mallepell Cristian R. Smulski Mahya Eslami Antonius Rolink Edith Hummler Eileen Samy Yves Fomekong Nanfack Fabienne Mackay Maofu Liao Henry Hess Xuliang Jiang Pascal Schneider |
| spellingShingle |
Michele Vigolo Melissa G. Chambers Laure Willen Dehlia Chevalley Klaus Maskos Alfred Lammens Aubry Tardivel Dolon Das Christine Kowalczyk-Quintas Sonia Schuepbach-Mallepell Cristian R. Smulski Mahya Eslami Antonius Rolink Edith Hummler Eileen Samy Yves Fomekong Nanfack Fabienne Mackay Maofu Liao Henry Hess Xuliang Jiang Pascal Schneider A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors Nature Communications |
| author_facet |
Michele Vigolo Melissa G. Chambers Laure Willen Dehlia Chevalley Klaus Maskos Alfred Lammens Aubry Tardivel Dolon Das Christine Kowalczyk-Quintas Sonia Schuepbach-Mallepell Cristian R. Smulski Mahya Eslami Antonius Rolink Edith Hummler Eileen Samy Yves Fomekong Nanfack Fabienne Mackay Maofu Liao Henry Hess Xuliang Jiang Pascal Schneider |
| author_sort |
Michele Vigolo |
| title |
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors |
| title_short |
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors |
| title_full |
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors |
| title_fullStr |
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors |
| title_full_unstemmed |
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors |
| title_sort |
loop region of baff controls b cell survival and regulates recognition by different inhibitors |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-03-01 |
| description |
BAFF is an important cytokine for B cell survival, and is a therapeutic target for autoimmune disorders. Here the authors show that a 'flap' region of BAFF converts BAFFR binding events into survival signals and, with structural data, that this ‘flap’ differentially modulates binding of drugs such as belimumab or atacicept. |
| url |
https://doi.org/10.1038/s41467-018-03323-8 |
| work_keys_str_mv |
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