Assessment of hypertension association with arsenic exposure from food and drinking water in Bihar, India
Epidemiological studies have associated chronic exposure to arsenic (As) from drinking water with increased risk of hypertension. However, evidence of an association between As exposure from food and hypertension risks is sparse. To quantify the association between daily As intake from both food (ri...
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doaj-843fa366fa184f5082cf58ccc7537fb02021-08-18T04:20:17ZengElsevierEcotoxicology and Environmental Safety0147-65132021-10-01223112572Assessment of hypertension association with arsenic exposure from food and drinking water in Bihar, IndiaLingqian Xu0Sidharth Suman1Pushpa Sharma2Ranjit Kumar3Shatrunjay Kumar Singh4Nupur Bose5Ashok Ghosh6Mohammad Mahmudur Rahman7David A. Polya8Debapriya Mondal9Department of Earth and Environmental Sciences, Williamson Research Centre for Molecular Environmental Science, University of Manchester, Manchester M13 9PL, UKSchool of Science, Engineering & Environment, University of Salford, Salford M5 4WT, UK; Mahavir Cancer Institute and Research Center, Patna, IndiaMahavir Cancer Institute and Research Center, Patna, IndiaMahavir Cancer Institute and Research Center, Patna, IndiaDepartment of Environment and Water Management, A.N. College, Patna, IndiaDepartment of Environment and Water Management, A.N. College, Patna, India; Department of Geography, A.N. College, Patna, IndiaMahavir Cancer Institute and Research Center, Patna, IndiaGlobal Centre for Environmental Remediation (GCER), College of Engineering, Science and Environment, The University of Newcastle, Callaghan, NSW 2308, AustraliaDepartment of Earth and Environmental Sciences, Williamson Research Centre for Molecular Environmental Science, University of Manchester, Manchester M13 9PL, UKSchool of Science, Engineering & Environment, University of Salford, Salford M5 4WT, UK; Institute of Medical and Biomedical Education, St George’s University of London, London SW17 0RE, UK; Corresponding author at: Institute of Medical and Biomedical Education, St George’s University of London, London SW17 0RE, UK.Epidemiological studies have associated chronic exposure to arsenic (As) from drinking water with increased risk of hypertension. However, evidence of an association between As exposure from food and hypertension risks is sparse. To quantify the association between daily As intake from both food (rice, wheat and potatoes) and drinking water (Aswater) along with total exposure (Astotal) and hypertension risks in a study population in Bihar, India, we conducted an individual level cross-sectional analysis between 2017 and 2019 involving 150 participants. Arsenic intake variables and three indicators of hypertension risks (general hypertension, low-density lipoprotein (LDL) and high-density lipoprotein (HDL)) were derived, and any relationship was quantified using a series of crude and multivariable log-linear or logistic regression models. The prevalence of general hypertension was 40% for the studied population. The median level of HDL was 45 mg/dL while median value of LDL was 114 mg/dL. Apart from a marginally significant positive relationship between As intake from rice and the changes of LDL (p-value = 0.032), no significant positive association between As intake and hypertension risks could be ascertained. In fact, Astotal was found to be associated with lower risks of general hypertension and higher levels of HDL (p-value = 0.020 and 0.010 respectively) whilst general hypertension was marginally associated with lower Aswater (p-value = 0.043). Due to limitations regarding study design and residual confounding, all observed marginal associations should be treated with caution.http://www.sciencedirect.com/science/article/pii/S0147651321006849Arsenic intakeDrinking waterRiceWheatHypertensionBihar |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lingqian Xu Sidharth Suman Pushpa Sharma Ranjit Kumar Shatrunjay Kumar Singh Nupur Bose Ashok Ghosh Mohammad Mahmudur Rahman David A. Polya Debapriya Mondal |
spellingShingle |
Lingqian Xu Sidharth Suman Pushpa Sharma Ranjit Kumar Shatrunjay Kumar Singh Nupur Bose Ashok Ghosh Mohammad Mahmudur Rahman David A. Polya Debapriya Mondal Assessment of hypertension association with arsenic exposure from food and drinking water in Bihar, India Ecotoxicology and Environmental Safety Arsenic intake Drinking water Rice Wheat Hypertension Bihar |
author_facet |
Lingqian Xu Sidharth Suman Pushpa Sharma Ranjit Kumar Shatrunjay Kumar Singh Nupur Bose Ashok Ghosh Mohammad Mahmudur Rahman David A. Polya Debapriya Mondal |
author_sort |
Lingqian Xu |
title |
Assessment of hypertension association with arsenic exposure from food and drinking water in Bihar, India |
title_short |
Assessment of hypertension association with arsenic exposure from food and drinking water in Bihar, India |
title_full |
Assessment of hypertension association with arsenic exposure from food and drinking water in Bihar, India |
title_fullStr |
Assessment of hypertension association with arsenic exposure from food and drinking water in Bihar, India |
title_full_unstemmed |
Assessment of hypertension association with arsenic exposure from food and drinking water in Bihar, India |
title_sort |
assessment of hypertension association with arsenic exposure from food and drinking water in bihar, india |
publisher |
Elsevier |
series |
Ecotoxicology and Environmental Safety |
issn |
0147-6513 |
publishDate |
2021-10-01 |
description |
Epidemiological studies have associated chronic exposure to arsenic (As) from drinking water with increased risk of hypertension. However, evidence of an association between As exposure from food and hypertension risks is sparse. To quantify the association between daily As intake from both food (rice, wheat and potatoes) and drinking water (Aswater) along with total exposure (Astotal) and hypertension risks in a study population in Bihar, India, we conducted an individual level cross-sectional analysis between 2017 and 2019 involving 150 participants. Arsenic intake variables and three indicators of hypertension risks (general hypertension, low-density lipoprotein (LDL) and high-density lipoprotein (HDL)) were derived, and any relationship was quantified using a series of crude and multivariable log-linear or logistic regression models. The prevalence of general hypertension was 40% for the studied population. The median level of HDL was 45 mg/dL while median value of LDL was 114 mg/dL. Apart from a marginally significant positive relationship between As intake from rice and the changes of LDL (p-value = 0.032), no significant positive association between As intake and hypertension risks could be ascertained. In fact, Astotal was found to be associated with lower risks of general hypertension and higher levels of HDL (p-value = 0.020 and 0.010 respectively) whilst general hypertension was marginally associated with lower Aswater (p-value = 0.043). Due to limitations regarding study design and residual confounding, all observed marginal associations should be treated with caution. |
topic |
Arsenic intake Drinking water Rice Wheat Hypertension Bihar |
url |
http://www.sciencedirect.com/science/article/pii/S0147651321006849 |
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