THE CONTROVERSIAL ROLE OF PLACENTAL MICROBIOME IN PRETERM BIRTH

• Main Authors: Valentin Varlas, Ovidiu Peneș, Ioanina Părlătescu
• Format: Article
• Language: English
• Published: Amaltea Medical Publishing House 2021-06-01
• Series: Romanian Journal of Infectious Diseases
• Subjects: maternal microbiome; preterm birth; placental microbiome; pregnancy
• Online Access: https://rjid.com.ro/articles/2021.2/RJID_2021_2_Art-03.pdf

The correlation between the maternal and neonatal microbiome helps to understand the mechanisms that govern the metabolic and immune processes of the newborn. The literature of recent years brings pros and cons regarding the role of the placenta as a microbial residence and its involvement secondary to microbial colonization in premature birth. Additional multi-omics research will be needed to establish the role of this transient organ in elucidating the processes that govern premature birth. DNA sequencing has made it possible to identify microbial species in the human microbiome. Thus, the role of the maternal microbiome in pregnancy and related complications are partially elucidated. This article aimed to identify the diversity of species in the maternal placental microbiome, the possible association with the newborn microbiome, and the influence of dysbiosis in spontaneous premature birth (PTB). In pregnancy, the changes in the microbiome are multifactorial, and the analysis performed demonstrating the continuous intervention of the body in order to adapt the intestinal microbiota to have a positive maternal-fetal result.