Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I
Abstract Background Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity pri...
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doaj-844c0ffc8ef04d14b54c4b04e59c555d2021-05-30T11:47:54ZengBMCJournal of Neurodevelopmental Disorders1866-19471866-19552021-05-0113111910.1186/s11689-021-09364-3Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type IJannath Begum-Ali0Anna Kolesnik-Taylor1Isabel Quiroz2Luke Mason3Shruti Garg4Jonathan Green5Mark H. Johnson6Emily J. H. Jones7the STAARS and EDEN TeamsCentre for Brain and Cognitive Development, Birkbeck, University of LondonCentre for Brain and Cognitive Development, Birkbeck, University of LondonCentre for Brain and Cognitive Development, Birkbeck, University of LondonCentre for Brain and Cognitive Development, Birkbeck, University of LondonDivision of Neuroscience and Experimental Psychology, University of ManchesterDivision of Neuroscience and Experimental Psychology, University of ManchesterCentre for Brain and Cognitive Development, Birkbeck, University of LondonCentre for Brain and Cognitive Development, Birkbeck, University of LondonAbstract Background Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. Methods In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. Results In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. Conclusions These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD.https://doi.org/10.1186/s11689-021-09364-3Neurofibromatosis type 1Auditory processingHabituationChange detectionEEGAutism spectrum disorder |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jannath Begum-Ali Anna Kolesnik-Taylor Isabel Quiroz Luke Mason Shruti Garg Jonathan Green Mark H. Johnson Emily J. H. Jones the STAARS and EDEN Teams |
spellingShingle |
Jannath Begum-Ali Anna Kolesnik-Taylor Isabel Quiroz Luke Mason Shruti Garg Jonathan Green Mark H. Johnson Emily J. H. Jones the STAARS and EDEN Teams Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I Journal of Neurodevelopmental Disorders Neurofibromatosis type 1 Auditory processing Habituation Change detection EEG Autism spectrum disorder |
author_facet |
Jannath Begum-Ali Anna Kolesnik-Taylor Isabel Quiroz Luke Mason Shruti Garg Jonathan Green Mark H. Johnson Emily J. H. Jones the STAARS and EDEN Teams |
author_sort |
Jannath Begum-Ali |
title |
Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I |
title_short |
Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I |
title_full |
Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I |
title_fullStr |
Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I |
title_full_unstemmed |
Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I |
title_sort |
early differences in auditory processing relate to autism spectrum disorder traits in infants with neurofibromatosis type i |
publisher |
BMC |
series |
Journal of Neurodevelopmental Disorders |
issn |
1866-1947 1866-1955 |
publishDate |
2021-05-01 |
description |
Abstract Background Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. Methods In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. Results In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. Conclusions These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD. |
topic |
Neurofibromatosis type 1 Auditory processing Habituation Change detection EEG Autism spectrum disorder |
url |
https://doi.org/10.1186/s11689-021-09364-3 |
work_keys_str_mv |
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