Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit

Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit

How neuronal migration and axon growth coordinate during development is only partially understood. Here the authors use quantitative imaging to characterise the morphogenesis of the zebrafish olfactory placode and report an unexpected phenomenon, whereby axons extend through the passive movement of...

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Main Authors: M. A. Breau, I. Bonnet, J. Stoufflet, J. Xie, S. De Castro, S. Schneider-Maunoury
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00283-3
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spelling doaj-8453dab367704a8e9488eeb9e4ab12f72021-01-31T12:42:40ZengNature Publishing GroupNature Communications2041-17232017-08-018111410.1038/s41467-017-00283-3Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuitM. A. Breau0I. Bonnet1J. Stoufflet2J. Xie3S. De Castro4S. Schneider-Maunoury5Institut de Biologie Paris-Seine (IBPS)—Developmental Biology LaboratorySorbonne UniversitésInstitut de Biologie Paris-Seine (IBPS)—Developmental Biology LaboratoryInstitut de Biologie Paris-Seine (IBPS)—Developmental Biology LaboratoryInstitut de Biologie Paris-Seine (IBPS)—Developmental Biology LaboratoryInstitut de Biologie Paris-Seine (IBPS)—Developmental Biology LaboratoryHow neuronal migration and axon growth coordinate during development is only partially understood. Here the authors use quantitative imaging to characterise the morphogenesis of the zebrafish olfactory placode and report an unexpected phenomenon, whereby axons extend through the passive movement of neuron cell bodies away from tethered axon tips.https://doi.org/10.1038/s41467-017-00283-3
collection DOAJ
language English
format Article
sources DOAJ
author M. A. Breau
I. Bonnet
J. Stoufflet
J. Xie
S. De Castro
S. Schneider-Maunoury
spellingShingle M. A. Breau
I. Bonnet
J. Stoufflet
J. Xie
S. De Castro
S. Schneider-Maunoury
Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit
Nature Communications
author_facet M. A. Breau
I. Bonnet
J. Stoufflet
J. Xie
S. De Castro
S. Schneider-Maunoury
author_sort M. A. Breau
title Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit
title_short Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit
title_full Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit
title_fullStr Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit
title_full_unstemmed Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit
title_sort extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-08-01
description How neuronal migration and axon growth coordinate during development is only partially understood. Here the authors use quantitative imaging to characterise the morphogenesis of the zebrafish olfactory placode and report an unexpected phenomenon, whereby axons extend through the passive movement of neuron cell bodies away from tethered axon tips.
url https://doi.org/10.1038/s41467-017-00283-3
work_keys_str_mv AT mabreau extrinsicmechanicalforcesmediateretrogradeaxonextensioninadevelopingneuronalcircuit
AT ibonnet extrinsicmechanicalforcesmediateretrogradeaxonextensioninadevelopingneuronalcircuit
AT jstoufflet extrinsicmechanicalforcesmediateretrogradeaxonextensioninadevelopingneuronalcircuit
AT jxie extrinsicmechanicalforcesmediateretrogradeaxonextensioninadevelopingneuronalcircuit
AT sdecastro extrinsicmechanicalforcesmediateretrogradeaxonextensioninadevelopingneuronalcircuit
AT sschneidermaunoury extrinsicmechanicalforcesmediateretrogradeaxonextensioninadevelopingneuronalcircuit
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