Boron-doped nanocrystalline diamond electrodes for neural interfaces: In vivo biocompatibility evaluation
Boron-doped nanocrystalline diamond (BDD) electrodes have recently attracted attention as materials for neural electrodes due to their superior physical and electrochemical properties, however their biocompatibility remains largely unexplored. In this work, we aim to investigate the in vivo biocompa...
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2016-03-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00087/full |
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doaj-8459dc3923564118ba8862714a1d23ba2020-11-24T23:17:05ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2016-03-011010.3389/fnins.2016.00087172251Boron-doped nanocrystalline diamond electrodes for neural interfaces: In vivo biocompatibility evaluationMaría eAlcaide0Andrew eTaylor1Andrew eTaylor2Morten eFjorback3Vladimir eZachar4Cristian Pablo Pennisi5Aalborg UniversityInstitute of PhysicsNano6 s.r.o.Neurodan a/sAalborg UniversityAalborg UniversityBoron-doped nanocrystalline diamond (BDD) electrodes have recently attracted attention as materials for neural electrodes due to their superior physical and electrochemical properties, however their biocompatibility remains largely unexplored. In this work, we aim to investigate the in vivo biocompatibility of BDD electrodes in relation to conventional titanium nitride (TiN) electrodes using a rat subcutaneous implantation model. High quality BDD films were synthesized on electrodes intended for use as an implantable neurostimulation device. After implantation for 2 and 4 weeks, tissue sections adjacent to the electrodes were obtained for histological analysis. Both types of implants were contained in a thin fibrous encapsulation layer, the thickness of which decreased with time. Although the level of neovascularization around the implants was similar, BDD electrodes elicited significantly thinner fibrous capsules and a milder inflammatory reaction at both time points. These results suggest that BDD films may constitute an appropriate material to support stable performance of implantable neural electrodes over time.http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00087/fullBiocompatible Materialsin vivo modelsneural electrodesTitanium nitrideforeign body reactionBoron-doped diamond electrode |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
María eAlcaide Andrew eTaylor Andrew eTaylor Morten eFjorback Vladimir eZachar Cristian Pablo Pennisi |
spellingShingle |
María eAlcaide Andrew eTaylor Andrew eTaylor Morten eFjorback Vladimir eZachar Cristian Pablo Pennisi Boron-doped nanocrystalline diamond electrodes for neural interfaces: In vivo biocompatibility evaluation Frontiers in Neuroscience Biocompatible Materials in vivo models neural electrodes Titanium nitride foreign body reaction Boron-doped diamond electrode |
author_facet |
María eAlcaide Andrew eTaylor Andrew eTaylor Morten eFjorback Vladimir eZachar Cristian Pablo Pennisi |
author_sort |
María eAlcaide |
title |
Boron-doped nanocrystalline diamond electrodes for neural interfaces: In vivo biocompatibility evaluation |
title_short |
Boron-doped nanocrystalline diamond electrodes for neural interfaces: In vivo biocompatibility evaluation |
title_full |
Boron-doped nanocrystalline diamond electrodes for neural interfaces: In vivo biocompatibility evaluation |
title_fullStr |
Boron-doped nanocrystalline diamond electrodes for neural interfaces: In vivo biocompatibility evaluation |
title_full_unstemmed |
Boron-doped nanocrystalline diamond electrodes for neural interfaces: In vivo biocompatibility evaluation |
title_sort |
boron-doped nanocrystalline diamond electrodes for neural interfaces: in vivo biocompatibility evaluation |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2016-03-01 |
description |
Boron-doped nanocrystalline diamond (BDD) electrodes have recently attracted attention as materials for neural electrodes due to their superior physical and electrochemical properties, however their biocompatibility remains largely unexplored. In this work, we aim to investigate the in vivo biocompatibility of BDD electrodes in relation to conventional titanium nitride (TiN) electrodes using a rat subcutaneous implantation model. High quality BDD films were synthesized on electrodes intended for use as an implantable neurostimulation device. After implantation for 2 and 4 weeks, tissue sections adjacent to the electrodes were obtained for histological analysis. Both types of implants were contained in a thin fibrous encapsulation layer, the thickness of which decreased with time. Although the level of neovascularization around the implants was similar, BDD electrodes elicited significantly thinner fibrous capsules and a milder inflammatory reaction at both time points. These results suggest that BDD films may constitute an appropriate material to support stable performance of implantable neural electrodes over time. |
topic |
Biocompatible Materials in vivo models neural electrodes Titanium nitride foreign body reaction Boron-doped diamond electrode |
url |
http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00087/full |
work_keys_str_mv |
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