GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis
Abstract Growth differentiation factor 11 (GDF11) is a transforming factor-β superfamily member that functions as a negative regulator of neurogenesis during embryonic development. However, when recombinant GDF11 (rGDF11) is administered systemically in aged mice, it promotes neurogenesis, the oppos...
Main Authors: | Brittany A. Mayweather, Sean M. Buchanan, Lee L. Rubin |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-09-01
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Series: | Molecular Brain |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13041-021-00845-z |
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