CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions

CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions

Microglia are specialized brain macrophages that play numerous roles in tissue homeostasis and response to injury. Colony stimulating factor 1 receptor (CSF1R) is a receptor tyrosine kinase required for the development, maintenance, and proliferation of microglia. Here we show that in adult mice per...

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Bibliographic Details
Main Authors: Courtney Easley-Neal, Oded Foreman, Neeraj Sharma, Ali A. Zarrin, Robby M Weimer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Csf1r
Csf1
IL-34
microglia
CNS
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02199/full

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