Reversible acral and mucosal hyperpigmentation in a patient with B12 deficiency secondary to polyglandular autoimmune syndrome type II

Reversible acral and mucosal hyperpigmentation in a patient with B12 deficiency secondary to polyglandular autoimmune syndrome type II

Reversible cutaneous hyperpigmentation often occurs in the setting of nutritional deficiencies and protein energy malnourishment, with atypical presentations arising from autoimmune disease. Here, we present a 52-year-old female with hypertension, type 1 diabetes, and Hashimoto’s thyroiditis, under...

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Main Authors: Ishan Asokan, Rachel Wheatley, Jenna Lullo, Meiling Yuen, Jan Smogorzewski
Format: Article
Language:English
Published: SAGE Publishing 2020-12-01
Series:SAGE Open Medical Case Reports
Online Access:https://doi.org/10.1177/2050313X20979207
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spelling doaj-84679a34cf074274be27b60b222adf432020-12-15T01:03:54ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2020-12-01810.1177/2050313X20979207Reversible acral and mucosal hyperpigmentation in a patient with B12 deficiency secondary to polyglandular autoimmune syndrome type IIIshan Asokan0Rachel Wheatley1Jenna Lullo2Meiling Yuen3Jan Smogorzewski4Department of Medicine, UCLA Medical Center, Los Angeles, CA, USADivision of Dermatology, Harbor-UCLA Medical Center, Torrance, CA, USADivision of Dermatology, Harbor-UCLA Medical Center, Torrance, CA, USADivision of Dermatology, Harbor-UCLA Medical Center, Torrance, CA, USADivision of Dermatology, Harbor-UCLA Medical Center, Torrance, CA, USAReversible cutaneous hyperpigmentation often occurs in the setting of nutritional deficiencies and protein energy malnourishment, with atypical presentations arising from autoimmune disease. Here, we present a 52-year-old female with hypertension, type 1 diabetes, and Hashimoto’s thyroiditis, under the diagnosis of polyglandular autoimmune syndrome type II, referred for evaluation of asymptomatic hyperpigmentation of the palms, soles, hard palate, and tongue for 6 months. The patient underwent a significant work-up, including esophagogastroduodenoscopy, which revealed hypertrophic gastropathy as well as evidence of acquired B12 deficiency secondary to pernicious anemia. The patient was initiated on B12 supplementation, with eventual resolution of mucocutaneous findings.https://doi.org/10.1177/2050313X20979207
collection DOAJ
language English
format Article
sources DOAJ
author Ishan Asokan
Rachel Wheatley
Jenna Lullo
Meiling Yuen
Jan Smogorzewski
spellingShingle Ishan Asokan
Rachel Wheatley
Jenna Lullo
Meiling Yuen
Jan Smogorzewski
Reversible acral and mucosal hyperpigmentation in a patient with B12 deficiency secondary to polyglandular autoimmune syndrome type II
SAGE Open Medical Case Reports
author_facet Ishan Asokan
Rachel Wheatley
Jenna Lullo
Meiling Yuen
Jan Smogorzewski
author_sort Ishan Asokan
title Reversible acral and mucosal hyperpigmentation in a patient with B12 deficiency secondary to polyglandular autoimmune syndrome type II
title_short Reversible acral and mucosal hyperpigmentation in a patient with B12 deficiency secondary to polyglandular autoimmune syndrome type II
title_full Reversible acral and mucosal hyperpigmentation in a patient with B12 deficiency secondary to polyglandular autoimmune syndrome type II
title_fullStr Reversible acral and mucosal hyperpigmentation in a patient with B12 deficiency secondary to polyglandular autoimmune syndrome type II
title_full_unstemmed Reversible acral and mucosal hyperpigmentation in a patient with B12 deficiency secondary to polyglandular autoimmune syndrome type II
title_sort reversible acral and mucosal hyperpigmentation in a patient with b12 deficiency secondary to polyglandular autoimmune syndrome type ii
publisher SAGE Publishing
series SAGE Open Medical Case Reports
issn 2050-313X
publishDate 2020-12-01
description Reversible cutaneous hyperpigmentation often occurs in the setting of nutritional deficiencies and protein energy malnourishment, with atypical presentations arising from autoimmune disease. Here, we present a 52-year-old female with hypertension, type 1 diabetes, and Hashimoto’s thyroiditis, under the diagnosis of polyglandular autoimmune syndrome type II, referred for evaluation of asymptomatic hyperpigmentation of the palms, soles, hard palate, and tongue for 6 months. The patient underwent a significant work-up, including esophagogastroduodenoscopy, which revealed hypertrophic gastropathy as well as evidence of acquired B12 deficiency secondary to pernicious anemia. The patient was initiated on B12 supplementation, with eventual resolution of mucocutaneous findings.
url https://doi.org/10.1177/2050313X20979207
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AT meilingyuen reversibleacralandmucosalhyperpigmentationinapatientwithb12deficiencysecondarytopolyglandularautoimmunesyndrometypeii
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