Diagnostic Value of Troponin I and T to Predict Mortality in Patients Undergoing Hemodialysis

• Main Authors: Seyed Taghi Hashemi, Babak Alikiaii, Samira Ghasemi
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2018-04-01
• Series: Archives of Anesthesia and Critical Care
• Subjects: Hemodialysis; Troponin T; Troponin I; Mortality.
• Online Access: https://aacc.tums.ac.ir/index.php/aacc/article/view/167

Background: There is no known biomarker to predict the mortality risk in patients undergoing dialysis in the intensive care unit (ICU). Therefore, the current study aimed to determine the diagnostic value of troponin I and T in this respect. Methods: This prospective study included 70 patients, admitted to the intensive care unit, during 2016-2017, who need hemodialysis. In these participants, the serum levels of troponin T and I were measured and the result of treatment was recorded in the patient’s profile whether it was improvement or death. Finally, we analyzed the diagnostic value of troponin T and I was predict the mortality in these patients in SPSS software version 20 through the Rock analysis. Results: The mean of troponin I and T levels in alive patients were 0.47±0.11 ng/ml and 0.67±0.15 ng/ml, respectively and in dead were 0.49±0.23 ng/ml and 1.06 ± 0.36 ng/ml, respectively. There was no significant difference between alive and dead patients in the mean of both troponins levels (P value> 0.05). On the other hand, Rock analysis also demonstrated that statistically these two biomarkers did not have any significant diagnostic value to predict mortality (P value> 0.05). Conclusion: According to the results, it is conceivable that troponin I and T are not proper biomarkers to predict the mortality in patients undergoing dialysis in ICU and these biomarkers do not have a proper sensitivity and specificity for this purpose.