Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage.
Kupffer cells are major determinants of outcome of liver injury. Their activity was therefore studied in a model of chronic liver disease. The effect of Tinospora cordifolia, an indigenous agent with proven hepatoprotective activity, was evaluated on Kupffer cell function, using carbon clearance tes...
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Wolters Kluwer Medknow Publications
1994-04-01
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doaj-84783a9d55fd45e1ac6c5cc5e7ed6a8c2020-11-25T01:46:24ZengWolters Kluwer Medknow PublicationsJournal of Postgraduate Medicine0022-38590972-28231994-04-01402657Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage.Nagarkatti DRege NDesai NDahanukar SKupffer cells are major determinants of outcome of liver injury. Their activity was therefore studied in a model of chronic liver disease. The effect of Tinospora cordifolia, an indigenous agent with proven hepatoprotective activity, was evaluated on Kupffer cell function, using carbon clearance test as a parameter. Rats were divided into two major groups. In Gp I which served as normal control t1/2 of carbon was 9.48 +/- 4.14 min. GpII received horse-serum in a dose of 0.5 ml/100 gm b.w. i.p. for a period of 12 weeks and was divided into three sub-groups. In Gp IIA at the end of 12 weeks half-life of carbon was found to be significantly increased to 19.86 +/- 7.95 min (p < 0.01). Indicating suppressed Kupffer cell function in chronic liver damage. In Gp IIB treated with vehicle for 4 more weeks there was significant prolongation of half-life to 38.32 +/- 10.61 min (p < 0.01), indicating perpetuation of damage in absence of damaging agent. Whereas in Gp IIc, treated with Tinospora cordifolia t 1/2 was decreased to 14.24 7.74 min (p < .01), as compared to vehicle control indicating a significant improvement in Kupffer cell function and a trend towards normalization.http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1994;volume=40;issue=2;spage=65;epage=7;aulast=NagarkattiAnalysis of VarianceAnimalCarbonpharmacokineticsDisease ModelsAnimalFemaleKupffer CellsphysiologyLiver FailuremetabolismphysiopathologytherapyMaleMetabolic Clearance RatePlantsMedicinalRats |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nagarkatti D Rege N Desai N Dahanukar S |
spellingShingle |
Nagarkatti D Rege N Desai N Dahanukar S Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. Journal of Postgraduate Medicine Analysis of Variance Animal Carbon pharmacokinetics Disease Models Animal Female Kupffer Cells physiology Liver Failure metabolism physiopathology therapy Male Metabolic Clearance Rate Plants Medicinal Rats |
author_facet |
Nagarkatti D Rege N Desai N Dahanukar S |
author_sort |
Nagarkatti D |
title |
Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. |
title_short |
Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. |
title_full |
Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. |
title_fullStr |
Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. |
title_full_unstemmed |
Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. |
title_sort |
modulation of kupffer cell activity by tinospora cordifolia in liver damage. |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Postgraduate Medicine |
issn |
0022-3859 0972-2823 |
publishDate |
1994-04-01 |
description |
Kupffer cells are major determinants of outcome of liver injury. Their activity was therefore studied in a model of chronic liver disease. The effect of Tinospora cordifolia, an indigenous agent with proven hepatoprotective activity, was evaluated on Kupffer cell function, using carbon clearance test as a parameter. Rats were divided into two major groups. In Gp I which served as normal control t1/2 of carbon was 9.48 +/- 4.14 min. GpII received horse-serum in a dose of 0.5 ml/100 gm b.w. i.p. for a period of 12 weeks and was divided into three sub-groups. In Gp IIA at the end of 12 weeks half-life of carbon was found to be significantly increased to 19.86 +/- 7.95 min (p < 0.01). Indicating suppressed Kupffer cell function in chronic liver damage. In Gp IIB treated with vehicle for 4 more weeks there was significant prolongation of half-life to 38.32 +/- 10.61 min (p < 0.01), indicating perpetuation of damage in absence of damaging agent. Whereas in Gp IIc, treated with Tinospora cordifolia t 1/2 was decreased to 14.24 7.74 min (p < .01), as compared to vehicle control indicating a significant improvement in Kupffer cell function and a trend towards normalization. |
topic |
Analysis of Variance Animal Carbon pharmacokinetics Disease Models Animal Female Kupffer Cells physiology Liver Failure metabolism physiopathology therapy Male Metabolic Clearance Rate Plants Medicinal Rats |
url |
http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1994;volume=40;issue=2;spage=65;epage=7;aulast=Nagarkatti |
work_keys_str_mv |
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