Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.
Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (clk-1, isp-1 and nuo-6) to identify overlapping genetic pathways that contribute to their longevity. We find that g...
Main Authors: | Megan M Senchuk, Dylan J Dues, Claire E Schaar, Benjamin K Johnson, Zachary B Madaj, Megan J Bowman, Mary E Winn, Jeremy M Van Raamsdonk |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-03-01
|
Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC5862515?pdf=render |
Similar Items
-
Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans.
by: Wenjing Qi, et al.
Published: (2012-01-01) -
Oxidative stress is increased in C. elegans models of Huntington’s disease but does not contribute to polyglutamine toxicity phenotypes
by: Emily Machiela, et al.
Published: (2016-12-01) -
Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.
by: Ji Li, et al.
Published: (2008-09-01) -
DAF-16/FOXO Transcription Factor in Aging and Longevity
by: Xiaojuan Sun, et al.
Published: (2017-08-01) -
CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16
by: Li Tao, et al.
Published: (2013-06-01)